ADME-Tox and DMPK

ADME-Tox and DMPK

Advance the development of your next therapeutic drug with easy-to-operate, integrated analytical systems that can provide new insights into ADME and DMPK. Rapidly and comprehensively characterize drug candidates with robust and sensitive solutions for identification, monitoring and quantitation.

Overview Workflows Resources

Overview

Confidently complete your ADME-Tox and DMPK studies across all drug development phases with dependable instruments run on intuitive, compliant-ready software. Fit-for-purpose LC-MS solutions enable pharmacokinetic parameter monitoring in complex matrices with excellent sensitivity and robustness, even for low-dose, highly potent drugs.

Workflows:

ADME-Tox studies DMPK and Bioanalysis studies

Workflow

ADME-Tox studies

Breeze through your routine ADME-Tox studies using highly sensitive and robust LC-MS solutions that have been designed to meet your team’s needs. Simplify monitoring of ADME-Tox parameters, even for highly potent drug substances in complex matrices, with compliant-ready SCIEX OS software.

Perform ADME-Tox studies with confidence using compliant-ready software
Achieve reliable and sensitive bioanalytical data using fit-for-purpose LC-MS solutions

ADME-Tox studies

Solution

Suited for:

Easily transfer methods when more sensitivity is required
Complete regulated and non-regulated ADME-Tox studies at any phase

ExionLC AE system

Reproducibility, reliability and carryover performance to match your quantitative workflows. Dependability you can count on, from injection to injection and batch after batch.

SCIEX Triple Quad 6500+ system

Delivering the perfect balance of speed, performance, and sensitivity for your most challenges analytes.

SCIEX OS software

Unleash the analytical power of the next-generation software platform for data acquisition and processing.

Service

Keep your instruments performing at their peak, with multiple options for response time, repair coverage and maintenance.

Featured resources

Highly sensitive LC-MS/MS method for the quantification of fluticasone propionate in human plasma

Observe a selective, sensitive and reproducible bioanalytical method for quantitation of fluticasone propionate in human plasma with a sub-picogram level LLOQ that is suitable for use in regulated bioanalytical laborator

ADME-Tox studies

Solution

Suited for:

Assays that need additional sensitivity

ExionLC AE system

Reproducibility, reliability and carryover performance to match your quantitative workflows. Dependability you can count on, from injection to injection and batch after batch.

SCIEX 7500 system

Detect the previously undetectable and quantify at lower levels than ever before with impressive precision.

SCIEX OS software

Unleash the analytical power of the next-generation software platform for data acquisition and processing.

Service

Keep your instruments performing at their peak, with multiple options for response time, repair coverage and maintenance.

Featured resources

Filter:

A sensitive method for the quantitative of formoterol in human plasma

Discover a sensitive method for the quantitation of the highly potent orally inhaled drug, formoterol, in human plasma. Highly reproducible performance was achieved with linearity demonstrated at concentrations ranging from 0.05 to 100 pg/mL.

Pharmacologically relevant measurement of high potency drug candidates with improved sensitivity in in-vitro transporter assays

Discover how the SCIEX 7500 system provides the high-quality data needed to improve compound rank ordering and selection in early-stage drug development.

Workflow

DMPK and Bioanalysis studies

Achieve robust DMPK and bioanalytical data with access to a range of integrated solutions that deliver reliable and trustworthy performance, even for highly potent and low-abundance compounds in complex matrices. Help ensure collection of reliable data using compliant-ready software backed by a team of technical experts ready to support your needs.

Achieve robust and sensitive performance, even for low-abundant compounds
Gain access to a trusted team of technical experts
Compliant-ready software

DMPK and Bioanalysis studies

Solution

Suited for:

Absolute sensitivity and quantitation
Demanding robustness

ExionLC AE system

Reproducibility, reliability and carryover performance to match your quantitative workflows. Dependability you can count on, from injection to injection and batch after batch.

SCIEX 7500 system

Detect the previously undetectable and quantify at lower levels than ever before with impressive precision.

SCIEX OS software

Unleash the analytical power of the next-generation software platform for data acquisition and processing.

Service

Keep your instruments performing at their peak, with multiple options for response time, repair coverage and maintenance.

Featured resources

Filter:

A sensitive method for the quantitation of formoterol in human plasma

See how a simple liquid-liquid extraction sample preparation protocol is used for accurate, reproducible, low-level (0.05 pg/mL) quantification of formoterol in human plasma.

Robustness of the SCIEX 7500 system for small molecule analysis in tissue

Learn more about the potential for high levels of robustness and repeatability in bioanalysis, demonstrated with two challenging samples and using 4,000 continuous injections of a rat liver homogenate.

Quantifying fluticasone propionate and salmeterol xinafoate with high sensitivity in human plasma

Review a highly sensitive, rapid LC-MS/MS method for simultaneous quantitation of two highly potent, low-dose inhalants in human plasma, with LLOQs in the 0.05 pg/mL range using 400 μL of plasma.

DMPK and Bioanalysis studies

Solution

Suited for:

Analytical flexibility allowing quan/qual work
Bioanalyses requiring additional selectivity or a high mass range

ExionLC AE system

Reproducibility, reliability and carryover performance to match your quantitative workflows. Dependability you can count on, from injection to injection and batch after batch.

ZenoTOF 7600 system

A high-resolution mass spectrometry solution that combines powerful MS/MS sensitivity, fragmentation technology and a step-change in data independent acquisition.

SCIEX OS software

Unleash the analytical power of the next-generation software platform for data acquisition and processing.

Service

Keep your instruments performing at their peak, with multiple options for response time, repair coverage and maintenance.

Featured resource

Confident identification of phase 1 metabolites using electron-activated dissociation (EAD)

Uncover how an orthogonal fragmentation technique provides complementary MS/MS spectral data, allowing rapid, software-aided characterization and identification of low-level metabolites in support of drug metabolism studies.

All resources

Filter:

A sensitive method for the quantification of formoterol in human plasma

See how a simple liquid-liquid extraction sample preparation protocol is used for accurate, reproducible, low-level (0.05 pg/mL) quantification of formoterol in human plasma.

Robustness of the SCIEX 7500 system for small molecule analysis in tissue

Learn more about the potential for high levels of robustness and repeatability in bioanalysis, demonstrated with two challenging samples and using 4,000 continuous injections of a rat liver homogenate.

Quantifying fluticasone propionate and salmeterol xinafoate with high sensitivity in human plasma

Review a highly sensitive, rapid LC-MS/MS method for simultaneous quantitation of two highly potent, low-dose inhalants in human plasma, with LLOQs in the 0.05 pg/mL range using 400 μL of plasma.

Highly sensitive LC-MS/MS method for the quantification of fluticasone propionate in human plasma

Observe a selective, sensitive and reproducible bioanalytical method for quantitation of fluticasone propionate in human plasma with a sub-picogram level LLOQ that is suitable for use in regulated bioanalytical laborator.

A sensitive method for the quantitation of formoterol in human plasma

See how a simple liquid-liquid extraction sample preparation protocol is used for accurate, reproducible, low-level (0.05 pg/mL) quantification of formoterol in human plasma.

Pharmacologically relevant measurement of high potency drug candidates with improved sensitivity in in-vitro transporter assays

Discover how the SCIEX 7500 System provides the higher quality data needed to improve compound rank ordering and selection in early-stage drug development.

Confident identification of phase 1 metabolites using electron-activated dissociation (EAD)

Uncover how an orthogonal fragmentation technique provides complementary MS/MS spectral data, allowing rapid, software-aided characterization and identification of low-level metabolites in support of drug metabolism studies.