SCIEX Triple Quad™ 3500 LC-MS/MS System

Welcome to the world of LC-MS/MS

If you’re currently running your assays using GC, GC-MS, or HPLC, a bold new world awaits you. Discover how the power of liquid chromatography (LC) coupled with triple quadrupole tandem mass spectrometry (MS/MS) can simplify and consolidate your current assays, dramatically increase your assay quality, and vastly expand the repertoire of assays you can provide – without breaking your budget. With the SCIEX Triple Quad™ 3500 LC-MS/MS system, modern hardware, powerful software, and robust engineering combine to enable lower levels of detection and quantitation than conventional GC and LC workflows, and across a wider range of analytes. You’ll get expert level performance at an entry level price.

Triple Quad 3500 System

SCIEX Triple Quad 3500 System Compendium

For challenging applications requiring identification and quantification of known and unknown analytes at low concentrations, the power of LC-MS is undisputable. Download the compendium to see the powerful capabilities of the SCIEX Triple Quad 3500 System.

GC-MS vs. LC-MS/MS

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Why SCIEX LC-MS/MS?
The SCIEX Triple Quad 3500 LC-MS/MS system combines the ease of liquid chromatography with its inherently broad analyte applicability, with the quantitative power of triple quadrupole tandem mass spectrometry (MS/MS).

The power of liquid chromatography for separation (LC)
Simplify sample preparation and reduce contamination

Liquid chromatography is amenable to the analysis of a wide array of analytes. In fact, many compounds that are difficult to analyze by GC such as thermally labile and chemically unstable analytes, amines, and semi-volatile compounds, are ideal candidates for LC-MS/MS. GC based assays, including GC-FID and GCMS, typically require samples to be in an organic injection solvent. This often necessitates derivatization of hydrophilic analytes to improve their volatility, ionization, or peak shape. Although usually more straightforward, HPLC-UV and HPLC-DAD assays can also involve complicated sample preparation techniques and be labor intensive depending upon the compound class. In contrast, while LC-MS/MS sample preparation methods can include solid-phase extraction or liquid-liquid extraction, they are often as simple as direct injection, dilution, or protein precipitation. By minimizing sample handling and decreasing the number of sample preparation steps, not only are areas for contamination minimized, but time is saved as well. And with today’s ultra-high performance LC systems (UHPLC), you can save even more time with ultra-fast chromatographic separations.

The power of tandem mass spectrometry for analysis (MS/MS)
Increase selectivity and improve detection limit

Mass spectrometry has been used as a powerful back-end detector for chromatographic separation techniques for over 50 years. It not only acts as a physical detection device that marks the specific retention time for your analyte, but it also provides an additional layer of specificity by providing molecular weight information on each compound. Now imagine that power intensified. With tandem mass spectrometry (MS/MS) you’ll gain yet another level of selectivity through detection of analyte-specific product ions. Through a process called multiple reaction monitoring (MRM), analyte precursor ions are selected in the first stage of analysis, dissociated into fragment ions within the second stage, and selectively filtered and detected within the third stage of analysis. Thus, by sequentially selecting and fragmenting each analyte so that only analyte-specific product ions are detected, the specificity and sensitivity of the assay can be improved exponentially. Additionally, co-eluting analytes and samples within complex matrices that may have been problematic for other assays, can greatly benefit from the additive power that MS/MS provides.

The power of a triple quadrupole for quantitation (Triple Quad)
Save time and achieve the highest assay performance

When it comes to MS/MS for quantitation, the type of mass analyzer matters. Triple quadrupole based mass spectrometers offer the best combined specifications for speed, sensitivity, specificity, dynamic range, and multiplexing capabilities for targeted quantitative MRM analysis versus any other type of mass analyzer. They are truly the gold-standard for targeted detection and quantitation . With a triple quadrupole based LC-MS/MS system not only can you achieve greater performance for many of your traditional GC and HPLC based assays, but new analytes can be added and new assays can be created, continually expanding the portfolio of services you can provide with one instrument. With LC-MS/MS, there’s an assay for every molecule

The power of SCIEX as your partner (SCIEX)
Gain peace of mind with reliable, easy-to-use instrumentation

SCIEX has built their reputation on developing high quality, robust, and reliable instrumentation that customers world-wide have come to rely upon on a daily basis. We introduced the first commercial triple quadrupole instrument almost 40 years ago and from that day forward our research scientists have never stopped innovating and advancing mass spectrometry technology. Evolved from an industry leading legacy, the budget-friendly SCIEX Triple Quad™ 3500 LC-MS/MS system contains all of the robust quality engineering you expect from the SCIEX portfolio.

 

Key Features

Mass Range: 5-2,000 Da With the same wide mass range as our top-of-the-line triple quadrupole instruments, even high mass compounds will form multiply-charged ions within the range of the Triple Quad 3500 LC-MS/MS system so you don’t have to worry that you’ll miss anything.
Ionization: Electrospray Ionization (ESI) and Atmospheric Pressure Chemical Ionization (APCI) probes included The TurboIonSpray probe enables electrospray ionization and is mild enough to be used for even labile compounds. For ionization of compounds that do not readily form ions in solution such as non polar compounds, the atmospheric pressure chemical ionization (APCI) probe can be used and may provide better sensitivity.
Polarity Switching: 50 msec in MRM and Scheduled MRM modes Some analytes preferentially form positively charged ions and some form negatively charged ions. This can present a problem if both types exist within the same sample. With polarity switching, you don’t have to choose the polarity of your assay ahead of time. The Triple Quad 3500 LC-MS/MS system will flip back and forth between charge modes throughout your assay so you get the best sensitivity for every analyte.
Detector Type: AcQuRate Pulse Counting CEM The AcQuRate™ Pulse Counting Channel Electron Multiplier combines the latest in detector technology with a pulse counting overlap correction algorithm. This means more accurate and precise ion detection over a wide dynamic range while maintaining maximum sensitivity.
Scan Types: Q1 MS, Q3 MS, Product Ion, Precursor Ion, Neutral Loss or Gain, MRM Targeted MRM quantitation is just one of the many scan types this powerful instrument can perform. With the 3500 Triple Quad LC-MS/MS system you can take advantage of one of the many additional scan types such as a Product Ion scan for structural determination of an unknown compound, a Precursor Ion or Neutral Loss scan to detect only compounds within a specific class that share a common structural moiety, or a Q1 or Q3 scan to simply determine the mass of a compound. Alternatively, create an assay that combines multiple different scan types for the ultimate in flexibility.

The Triple Quad 3500 LC-MS/MS system enables the analysis of more compounds in every injection, lower quantitation limits, and increased sample volume and throughput productivity over conventional GC and LC workflows.

SCIEX Triple Quad 3500 System Food & Environment Guide

See what the 3500 System can do for your food and environment workflows.

Resources

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SCIEX Triple Quad 3500 Systems Site Planning Guide (RU)

SCIEX Triple Quad 3500 Systems Site Planning Guide (PL)

SCIEX Triple Quad 3500 Systems Site Planning Guide (PT)

SCIEX Triple Quad 3500 Systems Site Planning Guide (ZH)

SCIEX Triple Quad 3500 Systems Site Planning Guide (JA)

Rapid Analysis of Isothiazolinones Preservatives in Cosmetics and Food Contact Materials by LC-MS-MS

Determination of Six Antiepileptic Drugs in Serum by SCIEX Triple Quad System (ZH)

Determination of Aflatoxins B and G in Grain

A Rapid Screening and Quantitative LC-MS-MS Method of 189 Veterinary Drug Residues in Animal Food by Triple QuadTM 3500

Determination of Genotoxic Impurities 4-nitrophenol on SCIEX Triple Quad 3500

The Solution of Analysis 13 Nitrosamines in Drinking Water by LC-MS-MS

Establish a rapid and efficient method for the determination of nitrosamines in cosmetics and personal care products

Determination of Chloramphenicol Thiamphenicol and Florfenicol Residues in Fish

Determination of Tetracycline Antibiotic Residues in Animal-derived Food

Application of LC-MS/MS in Chinese Pharmacopoeia

Synchronous detection of 150 veterinary drugs and other compounds in blood and urine of livestock

Simultaneous determination of 16 sunscreens in Sunblock Cosmetics by Triple Quad 3500

Determination of Sulfonamide Residues in Chicken

A Sensitive and Robust New Method for Quantification of Sodium Picosulfate in Food by Triple QuadTM 3500

Determination of Linezolid and Fluconazole in Plasma by SCIEX Liquid Chromatography-Tandem Mass Spectrometry (ZH)

Simultaneous determination of 32 kinds of components in hair dyes by high performance liquid chromatography-mass spectrometry

Determination of 74 Pesticides and metabolites in Soil By LC-MS-MS

Determination of Beta-agonist Residues in Meat

Determination of 23 Phthalate Esters in Drinking Water By LC-MS-MS

Determination of Quinolone Residues in Animal-derived Food

Determination of 23 Phthalate Esters in Cosmetics By LC-MS-MS

LC-MS-MS Method for Rapid Determination of 8 Organic Explosives in soil

A Rapid Quantification and Screening of 30 Mycotoxins in Feed by LC-MS-MS

Quick Determination Potassium Butyl Xanthate in water by Triple Quad 3500 Mass Spectrometry

Determination of 8 Polar Pesticides and metabolites in Plasma and Urine Without Derivatization (ZH)

Determination of Aflatoxins B&G in Grain

Determination of Tetracycline Antibiotic Residues in Animal-derived Food

Determination of NMDA in Ranitidine Hydrochloride by LC-MS-MS

The LC-MS-MS Method for illegal cooking oil analysis by Triple Quad 3500

Determination of Nitrofuran Metabolites in Animal-derived Food

Determination of Caspofungin Posaconazole Voriconazole N-Oxide and Voriconazole in Plasma by SCIEX Liquid Chromatography-Tandem Mass Spectrometry

A Rapid Quantitative Method of LC-MS /MS for Dichlorvos in Sea Cucumbers (ZH)

Determination of Chloramphenicol Thiamphenicol and Florfenicol Residues in Fish

Simultaneous Determination of 7 Kinds of Local Anesthetics in Cosmetics by High Performance Liquid Chromatography-Mass Spectrometry (ZH)

Detection of Methylmalonic Aciduria by Ion Chromatography Tandem Mass Spectrometry (ZH)

Determination of Quinolone Residues in Animal-derived Food

A highly sensitive LC-MS/MS method for the analysis of tetracycline antibiotic residues in honey, developed using the SCIEX Triple Quad™ 3500 LC-MS/MS System

SCIEX 50th Anniversary - Special Offer

SCIEX vision Journal Issue 4

Determination of Beta-agonist Residues in Meat

List of Published Articles of Therapeutic Drug Monitorings (TDM) with SCIEX LC-MS/MS System (Volume 2)

List of Published Articles on Quantitative Methods of Clinical Diagnostics/Lab-Developed Tests (LDTs) with SCIEX LC-MS/MS System

Catalogue of Literatures on target lipidomics using Triple Quad QTRAP mass spectrometry (Volume 1)

Catalogue of Literatures on Metabolomics using SCIEX mass spectrometry (Volume 1)

List of Published Articles of Therapeutic Drug Monitorings (TDM) with SCIEX LC-MS/MS System (Volume 3)

List of Published Articles with SCIEX LC-MS-MS System-Clinical-Volume 4

Determination of Sulfonamide Residues in Chicken

Folder for The Flyers of Food Safety Monitoring Holistic Solution

List of Published Articles with SCIEX LC-MS-MS System-Clinical-Volume 3

List of Published Articles of Therapeutic Drug Monitorings (TDM) with SCIEX LC-MS/MS System (Volume 4)

Catalogue of Literatures on untarget lipidomics using SCIEX high resolution mass spectrometry (Volume 1)

List of Published Articles of Therapeutic Drug Monitorings (TDM) with SCIEX LC-MS/MS System (Volume 1)

Targeted analysis of extractables/leachables in drug products, containers and closuure systems

Quantitation of Psilocybin and Psilocybin in Mushroom by LC-MS/MS

Rapid DUID Screening of 17 Drugs of Abuse in Plasma and Saliva

Quantitation of acetamiprid & prochloraz in black pepper using the SCIEX Triple Quad™ 3500 System

Elevating the Forensic Laboratory Performance

Quantitation of multiple antibiotics in milk using the SCIEX Triple Quad™ 3500 LC-MS/MS System

Analysis of metronidazole & ronidazole in milk using the SCIEX Triple Quad™ 3500 System

Highly sensitive LC-MS/MS method for the quantification of pesticide residue in pepper using the SCIEX Triple QuadTM 3500 LC-MS/MS System

Bioanalytical Method transfer from the API 3200 System to the SCIEX Triple Quad 3500 and the Quantitative Bionalalysis of Efavirenz

Analysis of Streptomycin and its Metabolite in Honey Using the SCIEX Triple Quad 3500 System

Cannabis for Per Se Law Testing in Whole Blood using theSCIEX Triple Quad QTRAP 4500 LC-MS/MS System

Analysis of Nitrofuran Metabolites in Honey Using the SCIEX Triple Quad 3500 System

MRM Analysis of 26 Mycotoxins in Grain on a SCIEX Triple Quad™ 3500 System

Simultaneous quantification of aminoglycoside antibiotics in milk using the SCIEX Triple Quad™ 3500 System

Analysis of Sulfonamides in Honey Using the Triple Quad 3500 System

CYP4500 Protein Assay - Human Induction Kit Extended Panel

Rapid and Sensitive Detection of 8 Organic Explosives in Soil

Accomplish your analysis goals with the SCIEX Triple Quad 3500 LC-MS/MS System

Analysis of Streptomycin and its Metabolite in Milk Using the SCIEX Triple Quad 3500 System

Analysis of Sulfonamides in Milk Using the SCIEX Triple Quad 3500 System

Determination of Genotoxic Impurities Methyl benzenesulfonate and Ethyl benzenesulfonate on SCIEX Triple Quad 3500

Rapid Determination of 36 Anti-infective Drugs in Cosmetics by LC-MS-MS

Rapid Detection of SDHIs in tea by SCIEX Triple Quad LC-MS/MS system

Determination of Nitrofuran Metabolites in Animal-derived Food

Analysis of Vitamin E and Vitamin E Acetate in Vape Oils

Analysis of Chloramphenicol in Honey Using the SCIEX Triple Quad 3500 System

Fast Screening Method for 86 Forensic Analytes in Human Urine QTRAP 4500

Targeted Analysis of Extractables / Leachables in Drug Product, Containers and Closure Systems

Rapid, Sensitive, Quantitation method for Chloramphenicol in Meat using SCIEX Triple Quad 3500 LC-MS/MS System

Rapid Determination of Nitrosamines of Genotoxic Impurities in Metformin by Triple QuadTM 4500 System

Analysis of Pesticides in Food Samples Using the SCIEXTriple QuadTM 3500 System

A Rapid Screening and Quantitative LC-MS/MS Method of 40 Illegally added drugs in health-care food using SCIEX Triple Quad TM 3500 LC-MS/MS system

Applications of SCIEX LC-MS/MS System for Chinese Pharmacopedia (ZH)

Determination of Five Antibiotics and their Metabolites in Serum by SCIEX LC-MS/MS

SCIEX Tandem Mass Spectrometry Method for Quantification of Chondroitin Sulfate and Dermatan Sulfate by Methanolysis Derivatization

The Determination of Aflatoxins in Traditional Chinese Medicines using LC-MS/MS

The Determination of Zearalenone in Traditional Chinese Medicines using LC-MS/MS

LC-MS/MS法快速测定动物源食品中205种兽药的完整解决方案

LC-MS/MS 技术平台

Application of SCIEX 3500 triple quadrupole liquid chromatography mass spectrometry platform for the detection of 30 prohibited pesticides and their metabolites in Chinese herbal medicines and decoction pieces

SCIEX中国药典新规定的完整解决方案

基于SCIEX三重四极杆质谱系统对食品接触材料中丙烯酰胺迁移量的测定

Software  

Fast Screening Method for 86 Forensic Analytes in Human Urine QTRAP 4500

  • Release Date: 05.10.07
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SCIEX Triple Quad 3500 LC-MS/MS System - Discounted bundle for a limited time only

  • Version: Related to RUO-MKT-18-10405-A
  • Release Date: 10.23.19
  • File Size 721 KB
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Analysis of Vitamin E and Vitamin E Acetate in Vape Oils

  • Version: RUO-MKT-02-10498-A
  • Release Date: 10.22.19
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SCIEX Triple Quad 3500 System Food Environment Short Guide

  • Version: RUO-MKT-03-9490-A
  • Release Date: 07.22.19
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Analysis of Pesticides in Food Samples Using the AB SCIEX Triple Quad™ 3500 System

  • Version: RUO-MKT-02-9846-A
  • Release Date: 06.17.19
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