SCIEX Triple Quad™ 6500+ LC-MS/MS System

Revolutionary Sensitivity, Speed, and Performance with IonDrive™ Technology

The Triple Quad 6500+ LC-MS/MS system features multi-component IonDrive Technology including the IonDrive High Energy Detector+ that pushes the boundaries of LC-MS/MS quantitation farther than ever before. The revolutionary sensitivity, speed, and performance delivered through these technology enhancements enable you to see it all, from low mass to high mass compounds, in positive or negative polarity – in a single injection, with high sensitivity, reliability, and confidence.

  • Superior signal-to-noise and LOQ for the widest scope of chemical compounds in the most challenging matrices
  • Up to 6 orders of linear dynamic range for enhanced breadth of applications
  • Increased throughput with polarity switching speeds of 5 msec
  • No compromise in mass range with a 2000 m/z upper mass limit
  • Scan speeds of up to 12,000 Da/second for optimized UHPLC strategies
  • Compatible with SelexION®+ differential ion mobility
  • Enhanced ion transmission for added selectivity without compromising LOQs

The Triple Quad 6500+ system delivers revolutionary sensitivity, speed, and performance for your most challenging methods.

Triple Quad 6500+ System
Key Features

Mass Range

Triple quadrupole: 5 – 2,000 Da

Flexible Ionization Options

Options include OptiFlow Turbo V™ Electrospray (ESI) ionization and heated nebulizer ionization probes.

Selective, Robust and Powerful Ion Separation

Optional SelexION®+

Detector Type

IonDrive™ High Energy Detector+

Polarity Switching

5 msec in MRM and Scheduled MRM™ modes

More Ions with IonDrive Technology

Enhancements for the 6500+ Series

The production of more ions with the IonDrive™ Turbo V source is just one of the enhancements you will see with the Triple Quad 6500+. Also added is the ability to capture and transmit more ions with the unique IonDrive™ QJet guide and greater detection with the new IonDrive™ High Energy Detector+.

IonDrive Turbo V Source

The legendary Turbo V™ source increases ion production by using enhanced gas flow dynamics and optimized heater configuration to improve reliability, reproducibility, and robustness.

IonDrive QJet Guide

With its dual stage design, the IonDrive QJet Guide improves sensitivity and ion capture rate while focusing ions more efficiently than funnel approaches.

IonDrive High Energy Detector+

Pulse counting fundamentals achieve ultra sensitivity at the lower end, while increasing linearity at high count rates. The result is the collection of more ions across a broader dynamic range.

SelexION®+ DMS Technology

Ideal development suite for applications requiring the separation of isobaric species, isolation of challenging co-eluting contaminants, and reduction of high background noise.

Key Features

Mass Range

5-2000 Da

Features

IonDrive QJet, HED Detector

Detector Type

IonDrive High Energy Detector+ 

Scan Types

Q1 MS, Q3 MS, Product Ion, Precursor Ion, Neutral Loss or Gain, MRM, EMS, EPI, ER, MS3, MRM3

Ionization Sources/Options

IonDrive Turbo V; OptiFlow™ Turbo V; TurboIonSpray®; Atmospheric-pressure chemical ionization (APCI); DuoSpray™, Phytronix LDTD, Advion LESA Clarity, Digital PicoView, NanoSource, SelexION®+

Resources

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Echo MS Core Module System User Guide (ES)

User Guide: 6500 and 6500+ Series of Instruments Qualified Maintenance Person Guide (JA)

Echo MS System Site Planning Guide (IT)

Echo MS System Site Planning Guide

Echo MS System Site Planning Guide (JA)

Echo MS System Site Planning Guide (DE)

Echo MS System Site Planning Guide (KO)

Echo MS System Site Planning Guide (ES)

Echo MS System Site Planning Guide (ZH)

Echo MS System Site Planning Guide (FR)

Echo MS System Site Planning Guide (PT)

6500+ Series of Instruments Site Planning Guide (ZH)

Source d’ions IonDrive Turbo V Guide de l'opérateur

Sorgente di ionizzazione OptiFlow Turbo V Guida per l'operatore

IonDrive Turbo V Ion Source Operator Guide

OptiFlow Turbo Vイオン源 オペレータガイド

Fonte de íons OptiFlow Turbo V Guia do operador

OptiFlow Turbo V-Ionenquelle Bedienerhandbuch

OptiFlow Turbo V 离子源 操作员指南

OptiFlow Turbo V Ion Source 작업자 안내서

Sorgente di ionizzazione IonDrive Turbo V Guida per l'operatore

Fuente de iones OptiFlow Turbo V Guía del operador

IonDrive Turbo V 离子源 操作员指南

IonDrive Turbo V Ion Source 작업자 안내서

Source d'ions OptiFlow Turbo V Guide de l'opérateur

Fonte de íons IonDrive Turbo V Guia do operador

Fuente de iones IonDrive Turbo V Guía del operador

IonDrive Turbo Vイオン源 オペレータガイド

OptiFlow Turbo V Ion Source Operator Guide

Quantification of Dopamine, Epinephrine, Norepinephrine in Human Plasma by SCIEX Liquid Chromatography-Tandem Mass Spectrometry

SCIEX LC-MS-MS Application Technology on Origin Identification of Dairy Products based on Alpha-lactalbumin and Beta-lactoglobulin

Determination of Six Antiepileptic Drugs in Serum by SCIEX Triple Quad System (ZH)

Determination of Aflatoxins B and G in Grain

A Rapid Screening and Quantitative LC-MS-MS Method of 189 Veterinary Drug Residues in Animal Food by Triple QuadTM 3500

Determination of 38 Bile Acids in Biological Samples on SCIEX Triple Quad 5500 system

LC-MS-MS Method for Determination of 523 Pesticide Residues in Traditional Chinese Medicine

The Solution of Analysis 13 Nitrosamines in Drinking Water by LC-MS-MS

Determination of Six Antipsychotic Drugs in Serum by SCIEX Liquid Chromatography-Tandem Mass Spectrometry

Determination of beta-Amyloid Peptide in Human Cerebrospinal Fluid

Targeted Analysis of Eicosanoid in Plasma by LC-MS-MS

Establish a rapid and efficient method for the determination of nitrosamines in cosmetics and personal care products

Determination of Chloramphenicol Thiamphenicol and Florfenicol Residues in Fish

Determination of Tetracycline Antibiotic Residues in Animal-derived Food

Quantification of 74 Prohibited Hormones in Cosmetics Using LC-MS-MS System

Determination of Liposoluble Vitamins in Micro Blood Samples by SCIEX Liquid Chromatography Tandem Mass Spectrometry

Determination of Sulfonamide Residues in Chicken

Determination of Malachite Green and Crystal Violet Residues in Fish

Determination of 74 Pesticides and metabolites in Soil By LC-MS-MS

Determination of Beta-agonist Residues in Meat

Rapid Screening and Quantification of 223 Illegal Drug Residue in Feed Using LC-MS/MS (ZH)

Rapid Screening of Phenyl-sulfonate Ester Genotoxic Impurities by pMRM-IDA-EPI

Determination of 23 Phthalate Esters in Drinking Water By LC-MS-MS

Determination of Quinolone Residues in Animal-derived Food

Determination of Animal Species Origin from Blood Products by LC-MS-MS

A Rapid Screening and Quantitative LC-MS/MS Method of 247 PPCPs and Pesticide Residues in Water by Large Volume Injection

Determination of Bongkrekic Acid in Rice Noodles and Tremella on SCIEX Triple QuadTM 4500 System

Determination of Malachite Green and Crystal Violet Residues in Fish

Determination of trace angiotensin II in plasma with SCIEX Triple Quad 4500 LC-MS/MS system (ZH)

Determination of 13 Bile Acids in Serum by SCIEX Liquid Chromatography-Tandem Mass Spectrometry

Determination of 8 Polar Pesticides and metabolites in Plasma and Urine Without Derivatization (ZH)

Simultaneous Determination of Aldosterone and Angiotensin I from Human Plasma Using LC-MS/MS (ZH)

The Application of Analysis 13 Haloamides in Drinking Water by LC-MS-MS

Determination of Aflatoxins B&G in Grain

The Application Solution for Determination of Fluconazole and other 8 Kinds of Components in Cosmetics by LC-MS-MS Method

Determination of Tetracycline Antibiotic Residues in Animal-derived Food

Quantitation of 8 Fat Soluble Vitamins in Formula Infant Milk

Determination of NMDA in Ranitidine Hydrochloride by LC-MS-MS

Simultaneous Determination of 14 Paralytic Shellfish Toxins in Seafood using LC-MS-MS

Determination of Nitrofuran Metabolites in Animal-derived Food

Determination of 20 Steroid Hormones in Human Serum Samples by SCIEX Liquid Chromatography-Tandem Mass Spectrometry

Analysis 106 Compounds in Cell Supernatant by Using LC-MS-MS

Determination of Caspofungin Posaconazole Voriconazole N-Oxide and Voriconazole in Plasma by SCIEX Liquid Chromatography-Tandem Mass Spectrometry

Determination Trace Residues of Whey Protein in Lactose by LC-MS-MS

The power of SCIEX Triple Quad liquid chromatography tandem mass spectrometry to detect polycystic ovarian syndrome related androgen (ZH)

Determination of Chloramphenicol Thiamphenicol and Florfenicol Residues in Fish

Determination of seven Antineoplastic and antibacterial drugs in Serum by SCIEX LC-MS/MS

Simultaneous Determination of 7 Kinds of Local Anesthetics in Cosmetics by High Performance Liquid Chromatography-Mass Spectrometry (ZH)

SCIEX LC-MS-MS Application Technology on Quantitation of Lactoferrin in Dairy Products

Detection of 24 Perfluoroalkyl Substances in Surface water by Triple Quad TM 4500

Simultaneous quantitative analysis of metronidazole and chloramphenicol in chicken by SCIEX LC MS-MS

Simultaneous determination of five cytarabine metabolites and analogs with SelexION Ion mobility Mass Spectrum (ZH)

Detection of Methylmalonic Aciduria by Ion Chromatography Tandem Mass Spectrometry (ZH)

Determination of Quinolone Residues in Animal-derived Food

User Guide: 6500 and 6500+ Series of Instruments Qualified Maintenance Person Guide

Echo MS Core Module System User Guide

Echo MS Core Module System User Guide (DE)

Echo MS Core Module System User Guide (ZH)

Echo MS Core Module System User Guide (JA)

Echo MS Core Module System User Guide (KO)

Echo MS Core Module System User Guide (FR)

Echo MS Core Module System User Guide (IT)

Echo MS Core Module System User Guide (PT)

User Guide: 6500 and 6500+ Series of Instruments Qualified Maintenance Person Guide (ZH)

SCIEX vision Journal Issue 4

Compruebe y maximice la calidad de sus productos agriculturales

Determination of Beta-agonist Residues in Meat

List of Published Articles of Therapeutic Drug Monitorings (TDM) with SCIEX LC-MS/MS System (Volume 2)

List of Published Articles on Quantitative Methods of Clinical Diagnostics/Lab-Developed Tests (LDTs) with SCIEX LC-MS/MS System

Catalogue of Literatures on target lipidomics using Triple Quad QTRAP mass spectrometry (Volume 1)

Catalogue of Literatures on Metabolomics using SCIEX mass spectrometry (Volume 1)

List of Published Articles of Therapeutic Drug Monitorings (TDM) with SCIEX LC-MS/MS System (Volume 3)

List of Published Articles with SCIEX LC-MS-MS System-Clinical-Volume 4

Determination of Sulfonamide Residues in Chicken

Catalogue of Literatures on Traditional Chinese Medicine (Volume 1)

Folder for The Flyers of Food Safety Monitoring Holistic Solution

List of Published Articles with SCIEX LC-MS-MS System-Clinical-Volume 3

6500+ Brochure(ZH)

List of Published Articles with SCIEX LC-MS-MS System-Clinical-Volume 2

List of Published Articles of Therapeutic Drug Monitorings (TDM) with SCIEX LC-MS/MS System (Volume 4)

Catalogue of Literatures on untarget lipidomics using SCIEX high resolution mass spectrometry (Volume 1)

Catalogue of Literatures on Traditional Chinese Medicine (Volume 1)

List of Published Articles of Therapeutic Drug Monitorings (TDM) with SCIEX LC-MS/MS System (Volume 1)

Improve Sensitivity for Quantification of Antisense Oligonucleotides in Plasma Using Microflow LC-MRM Methodology

Highly sensitive LC-MS/MS workflow for targeted quantification of host cell proteins

Potency Analysis in Hemp and Cannabis Products using a Single-Dilution Combined LC-UV-MS/MS Approach

Fast and Simultaneous Analysis of Ethanol Metabolites and Barbiturates in Human Urine

Método LC-MS/MS Altamente Sensible para la Cuantificación de Barnidipino en Plasma Humano

No Slide Title

Direct analysis of polar pesticides in water: a routine accredited method

Multi-panel detection of drugs and drug metabolites in hair samples using a comprehensive extraction method

Fast Screening Method for 86 Forensic Analytes in Human Urine

Rapid, sensitive analysis of sphingolipid variant profiles with simplified sample extraction

Quantitation of Oregon List of Pesticides / Cannabinoids LC-MS/MS

A Clinical Research Method for the Measurement of Low-Level Testosterone in Serum using Differential Mobility Separation with LC-MS/MS

Identification and Quantification of Designer Drugs in Urine by LC-MS/MS

The Quantitative Power of SCIEX Triple Quad and the QTRAP® 6500+ LC- MS/MS System for the Bioanalysis of Biotherapeutics

No Slide Title

Quantification of Major Metabolites of K2 in Human Urine

Higher sensitivity analysis of a large panel of lipid mediators

Emerging food_QTRAP 6500+_PFFA food and food packaging_SCIEX_RUO-MKT-02-2755-A.docx

Análisis de Potencia en Productos de Cáñamo y Cannabis Utilizando un Enfoque Combinado de Dilución única LC-UV-MS / MS

Emerging food_QTRAP 6500+_sodium fluoroacetate_SCIEX_RUO-MKT-02-2756-A.docx

Rapid Detection of SDHIs in tea by SCIEX Triple Quad LC-MS/MS system

Determination of Nitrofuran Metabolites in Animal-derived Food

PT-Collaborative big data approaches

Fast Screening Method for 86 Forensic Analytes in Human Urine

Screening Solutions for Forensic Toxicology

Clinical Diagnostics Compendium Vol 2

Ultra-Sensitive Quantification of Trastuzumab Emtansine in Mouse Plasma using Trap-Elute MicroLC MS Method

Ultra-Sensitive Forensic Analysis Workflow of Cocaine and Metabolites in Hair Samples Using LC-MS/MS

PT-Industrialised proteomics large cancer cohorts

Universal Solution for Monoclonal Antibody Quantification in Biological Fluids Using Trap-Elute MicroLC-MS Method

PT-Chronic disease future healthcare and wellness testing

LC-MS/MS Screening and Quantification Methods for the Analysis of 41 Common Pain Drugs in an Oral Fluid Matrix

Front end cleaning of SCIEX Triple Quad™ and QTRAP® Systems

Improving Sensitivity for Trastuzamab Emtansine Quantification usign Trap-Elute MicroLC-MS with Large Volume Sample Loading

The Exposome of PFAS

Fast and Simultaneous Analysis of Ethanol Metabolites and Barbiturates in Human Urine

PT-Metabolomics and P4 healthcare

Sub-Picogram Level Quantitation of Desmopressin in Small Volumes of Human Plasma Using a Trap-Elute MicroLC-MS System

Introduction to LC-MS-MS

SCIEX Solutions for Cannabis Analysis

Extending the Lower Limits of Quantification of a Therapeutic Oligonucleotide Through Microflow LC-MS/MS

Simultaneous Determination of 14 Paralytic Shellfish Toxins using LC-MS/MS on SCIEX QTRAP® 6500+ System

Sub-pg Level Quant of Desmopressin in Small Volumes of Plasma using Microflow

Enabling New Levels of Quantification with SCIEX Triple Quad 7500 System

Rapid LC-MS-MS Method for the Analysis of Fipronil and Amitraz Insecticides

Forensic Compendium

Techniques and solutions for forensic drug screening: an interview with Timothy Fassette

The age of novel psychoactive substances

Determination of Five Antibiotics and their Metabolites in Serum by SCIEX LC-MS/MS

SCIEX Tandem Mass Spectrometry Method for Quantification of Chondroitin Sulfate and Dermatan Sulfate by Methanolysis Derivatization

The Determination of Aflatoxins in Traditional Chinese Medicines using LC-MS/MS

The Determination of Zearalenone in Traditional Chinese Medicines using LC-MS/MS

LC-MS/MS法快速测定动物源食品中205种兽药的完整解决方案

Approaches to drug screening using Triple Quadrupole, QTRAP and QTOF technologies

Harnessing the power of mass spectrometry for early novel psychoactive substances (NPS) detection

LC-MS/MS 技术平台

Challenges of screening and identifying NPS in the forensic laboratory

Application of SCIEX 3500 triple quadrupole liquid chromatography mass spectrometry platform for the detection of 30 prohibited pesticides and their metabolites in Chinese herbal medicines and decoction pieces

Novel Psychoactive Substances - Infographic

Detecting and identifying NPS: a brief history

The growing problem of NPS

Streamlining forensic laboratory informatics for NPS screening and quantification

Overcoming NPS screening challenges in the forensic laboratory

Detecting novel psychoactive substances - the workflow

SCIEX中国药典新规定的完整解决方案

基于SCIEX三重四极杆质谱系统对食品接触材料中丙烯酰胺迁移量的测定

SCIEX Triple Quad™ 6500+系统用于血浆中曲妥珠单抗含量的分析

Software

Chemical Standards
Part Number Kit Name/Instrument Description
4406127 MS Chemical Kit 1, Low-High Conc. PPGs Standards chemical kit with low/high concentrations of polypropylene glycol polymers (PPGs). This kit includes all solutions necessary for installation and calibration for all SCIEX Triple Quads, excluding the API 2000™ and API 3000™ instruments.
4412399 MS Chemical Kit2, Higher Conc. PPGs Standards chemical kit with High Concentrations PPGs. This kit includes all solutions necessary for installation and calibration for all API 2000 and 3000 instruments.
4465788 SelexION® Calibration Solution Installation and Calibration Solution for SelexION Ion Mobility Source.
5056819 Essential LCMS Performance Kit Environmental Certified QC kits for use on SCIEX Triple Quad and QTRAP® 4500, 5500, 6500 and 6500+ systems, coupled with high flow LC systems, to test performance in both positive and negative modes for Environmental applications.
5056822 Essential LCMS Performance Kit Toxicology Certified QC kits for use on SCIEX Triple Quad and QTRAP 4500, 5500, 6500 and 6500+ systems, coupled with high flow LC systems, to test performance in both positive and negative modes for Toxicology applications.
5056816 Essential LCMS Performance Kit Small Molecule Pharma Certified QC kits for use on SCIEX Triple Quad and QTRAP 4500, 5500, 6500 and 6500+ systems, coupled with high flow LC systems, to test performance in both positive and negative modes for Pharma (Small Molecule) applications.
5056815 Essential LCMS Performance Kit - Peptide

Certified QC kits for use on SCIEX Triple Quad and QTRAP 4500, 5500, 6500 and 6500+ systems, coupled with high flow LC systems, to test performance in positive mode for Peptide applications.