Organ-on-a-chip metabolomics

Dr. Thomas Hankemeier works with human in vitro models, known as “organ-on-a-chip”, to help predict clinical treatment outcomes and avoid fatalities.

06 / 22 / 2021 | Thomas Hankemeier

The LACDR team at Leiden University finds biomarkers for cardiovascular, metabolic, and neurological diseases, and then uses them to predict treatment outcomes. Dr. Thomas Hankemeier discusses the importance of using human cell samples to anticipate outcomes that might not be seen in animal models. Accurate mass technologies, crucial for studying their model systems, are highlighted.

“And what we found is that this compound, indeed, in animal models, up to the monkey, didn’t show any problems—but in human neurons and in human cell samples, it showed the problem.”

Thomas Hankemeier