Overview
Lead the development of novel targeted protein degradation (TPD) therapeutics such as proteolysis targeting chimeras (PROTACs). Bring novel drugs based on this new class of compounds to market with analytical systems that enable precise and accurate identification and quantitation of low-level targeted protein degraders, even in complex matrices.
Workflow
Targeted protein degrader quantitation
Develop sensitive assays using enhanced analytical systems that reliably detect nanomolar concentrations of highly potent targeted protein degraders. Achieve lower limits of quantitation (LLOQs) at the low-pg/mL level for the detection of targeted protein degraders in complex matrices with strong linearity and excellent accuracy and precision. Get to the important information quickly with fast, intuitive and integrated data acquisition and processing software.
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Achieve low-pg/mL quantitation of targeted protein degraders with excellent accuracy and precision
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Detect nanomolar concentrations of targeted protein degraders, even in complex matrices
Targeted protein degrader quantitation
Solution
ExionLC AE system
SCIEX 7500 system
SCIEX OS software
Service
Featured resources
Discover a highly sensitive assay for the quantitation of PROTACs in a complex matrix. Learn how innovative front-end enhancements achieved quantitation at low-pg/mL for a PROTAC and its inactive control in rat plasma.
Workflow
Targeted protein degrader quan/qual
Overcome challenges associated with detecting low levels of large targeted protein degraders active in complex matrices or limited sample quantities. Working with advanced mass spectrometry solutions enables your team to achieve high levels of sensitivity, ensure robust performance and streamline data management. High mass accuracy and MS/MS sensitivity over a wide mass range allows the use of simple sample preparation.
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Achieve high accuracy and sensitivity over a wide mass range
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Realize robust analytical performance across a broad linear dynamic range
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Gain the analytical flexibility to support each process
Targeted protein degrader quan/qual
Solution
ExionLC AE system
ZenoTOF 7600 system
SCIEX OS software
Service
Featured resources
Discover a sensitive and robust method for accurate quantitation of large PROTACs and their inactive controls in complex matrices. Learn about MRMHR workflow solutions with improved MS/MS sampling efficiency.
All resources
Discover a highly sensitive assay for the quantitation of PROTACs in a complex matrix. Learn how quantitation at low-pg/mL levels was achieved for a PROTAC and its inactive control in rat plasma with innovative front-end
Find out how PROTACs in complex matrices can be detected with high levels of sensitivity using a triple quadrupole mass spectrometer with enhanced ion generation, capture and transmission.
Discover a sensitive and robust method for accurate quantitation of large PROTACs and their inactive controls in complex matrices. Learn about MRMHR workflow solutions with improved MS/MS sampling efficiency.