You know what works, now push it further
Same foundation. More muscle.
The BioPhase 8800 system is a multi-capillary electrophoresis system that enables biopharma scientists to run multiple samples in parallel, accelerating the development and execution of sensitive, high-throughput analytical methods.
Take charge of the development pipeline, assess molecular liabilities more quickly, and enable rapid developability assessments to streamline the selection of candidates for progression into an effective therapy.
The BioPhase 8800 system is designed to advance your workflows into the next phase of biopharmaceutical development. With streamlined migration, consistent performance, and proven reliability, it’s the evolution that feels like home.
One platform, multiple ways to make it yours.
Gain valuable insights into quality attributes of biotherapeutics with kit-based assays and customizable features to address the evolving drug development pipeline. Ensure consistent, reproducible results with liquid temperature control, multiple injection modes, and simple switching between native fluorescence (NF), UV, or laser-induced fluorescence (LIF) detection modes.
Get to the answer sooner with a boost in throughput
- Parallel processing with 8 capillaries to speed up method development
- Equal separation voltage applied to each capillary for high reproducibility
- Factory-built cartridges and push-in loading reduce user error
Flexibility for your workflow requirements
- UV detection to enable bridging to legacy data
- NF detection for simplified peak identification, quantitation, and enhanced sensitivity.
- LIF detection for high-sensitivity detection of dye-labeled protein and oligos
Achieve consistent outcomes with precise temperature control
- Liquid-based temperature control of each capillary to maximize data reproducibility
- Uniform temperature control across the sample plate to maintain sample stability
- Rapid heating and cooling of sample chamber from 4-37°C to be ready for what’s next
Stay flexible with precise injection control
- High-precision, low-pressure injection mode to ensure uniform sample introduction
- Consistent pressure delivery for whole capillary filling
- Electrokinetic injection to maintain resolution
Quick and easy results with intuitive, large touchscreen interface
- Drag and drop method programming to create methods with ease
- Remote method and data analysis software at your desk
- Compatibility with Empower chromatography data system for data integrity.
Maximize productivity with kitted reagents and methods
- Support core analytical workflows
- Minimize method development
- Adapt to new modalities with ease
Multiple detector types
Integrated optical detection on the BioPhase 8800 system eliminates the need for manual detector changes, enabling seamless switching between detection modules. Choose NF, UV, or LIF depending on workflow needs.
Native fluorescence detection
Gain faster and more confident peak integration with significantly increased signal-to-noise ratio and a stable baseline.
NF detection offers increased sensitivity compared to traditional UV detection for CE-SDS, cIEF, and CZE assays. Eliminate the need for protein-fluorescence-dye conjugation during sample preparation.
Non-reduced CE-SDS analysis of NIST
IgG with NF detection:
Improved signal-to-noise ratio with NF results in a stable baseline and up to 10X improvement in sensitivity, allowing for faster interpretation and integration of peaks.
Enable quantitation of low-level impurities
UV detection can struggle to identify low-level impurities due to interference from baseline noise. NF detection reduces the baseline noise and enables the quantitation of low-level impurities down to 0.01%.
Charge heterogeneity analysis of NISTmAb on the BioPhase 8800 system with NF. Achieve equivalent data between UV and NFD for cIEF with a more stable baseline to enable better peak integration and identification of low abundant species.
Establish CE methods that meet today’s complexity and tomorrow’s pressure.
With kit-based CE workflows from SCIEX, your lab stays ready for what’s next, no rebuild required. Whether it’s a new modality, a shift in format, or an urgent timeline, respond without overhauling your system.
- CE-SDS – Determine the apparent molecular weight of proteins to evaluate the size heterogeneity, purity, and manufacturing consistency of biologics
Learn more > - CZE – Accelerate charge heterogeneity analysis with native capillary zone electrophoresis
Learn more > - cIEF – Establish the identity and stability of the molecule with accurate determination of a protein’s charge heterogeneity
Learn more > - Fast glycan identification – Combine simplified sample preparation, rapid separations, and automated glycan identification to make confident decisions quickly
Learn more >
- mRNA purity and integrity – RNA integrity and quality analysis is critical to ensuring the efficacy of RNA-based therapeutics and vaccines. Discover kit-based solutions designed for the separation of single-stranded oligonucleotides from 50-9,000 nucleotides and beyond
Learn more > - Purity of plasmid starting material – Assess linear DNA sizes and purity confidently with ultra-high resolution over a wide size range
Learn more >
- Capsid protein purity – Avoid lengthy assay adjustments with a kit-based protein profiling workflow suitable across serotypes and viral vectors
Learn more > - Virus genome integrity – Confidently determine genome integrity, genome titer, and impurities
Learn more > - Empty full capsid ratio – Determine multiple CQAs, including full-and-empty ratios, on one platform
Learn more > - Purity of plasmids - Determine the purity of supercoiled critical starting material across a wide size range
Learn more > - Host cell nucleic acids – Assess residual nucleic acid sizes and quantities simultaneously
Learn more >
- Purity and integrity of sgRNA and mRNA – Understand related nucleic acid impurities and determine sizes and quantities over a wide size range (50 to 9,000 nt)
Learn more > - Purity of plasmid starting material – Assess linear DNA sizes and purity confidently with ultra-high resolution over a wide size range
Learn more >
Expand what’s possible using what’s already proven.
Discover how your peers in the biopharma world are rewriting the rules of CE in drug development. Wherever you play in the pipeline, change the game in modern medicine.
Upstream process development
- Cell line selection
Read case study > - Cell line development
Read case study > - Master cell bank creation
Downstream process development
- Bioreactor optimization
Register for webinar > - Process intensification
Watch webinar > - Process analytical support
Watch webinar >
Analytical development
- Stability studies
Read case study > - Comparability assessment
Watch webinar > - Method development and validation
Read case study > - Support for regulatory filings
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PA 800 Plus systemTake advantage of a flexible platform for multiple analytical assays with a temperature-controlled capillary for the highest data reproducibility and confidence.
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Intabio ZT systemEliminate the guess work and monitor biologics at the intact-protein level, gaining insights into charge variant-associated quality attributes.
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CE kits and reagentsSupport core industry workflows with validated kits. Adapt quickly with kit-based workflows designed to support core industry assays on SCIEX CE instruments.
Learn more
Related applications
Reclaim time for innovation by identifying and advancing drug candidates more confidently with analytical strategies that support your team across modalities, from discovery to commercialization.
Messenger RNA analysis
Break through barriers and extend the frontiers of mRNA, saRNA, and circRNA development with intuitive analytical solutions. Confidently innovate with high-quality, sensitive, and accurate data to assess integrity, purity, and CQAs.
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Plasmid and DNA analysis
Advance your projects with purpose-built solutions for the analysis of pDNA and dsDNA to support the development of your mRN), viral vectors, recombinant proteins, and other new modalities.
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Viral vector characterization
Optimize your processes with solutions that overcome the analytical challenges of viral vector-based drugs. Take control of full and empty ratios and protein and genome profiles. Break down the boundaries of protein and post-translational modification (PTM) characterization with dedicated high-resolution workflows offering unprecedented depth.
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CRISPR/Cas9 analysis
Set your own schedule for CRISPR/Cas9 gene editing with innovative, intuitive analytical solutions. Unleash the potential of your Cas9 mRNa, sgRNA, and Cas9 proteins by understanding quality, purity, and safety and assessing on/off target effects.
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Cell line analysis
Set the pace with confidence. Cell line monitoring and analysis solutions verify the identity, purity, and stability of lead candidates with high throughput strategies that are ready for automation.
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Glycan analysis
Fully understand drug candidate glycoprofiles with pipeline-specific solutions. Gather critical high-resolution information and site-specific data points with advanced glycan analysis for complex biologic development.
Learn more
Charge heterogeneity analysis
Pursue the end goal with confidence. Achieve the full picture and accelerate decisions with comprehensive characterization of biopharmaceutical charge variants.
Learn more
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