PA 800 Plus system

Unlock the future with multiple biotherapeutic assays on one platform

The quality assessment of your biopharmaceuticals deserves the best. Using capillary electrophoresis (CE) on the PA800 Plus system lets you challenge the status quo and break through analytical boundaries.

Ultra-high quality separation day in and day out with intuitive kit-based applications for capillary capillary electrophoresis sodium dodecyl sulfate (CE-SDS), capillary gel electrophoresis (CGE), capillary isoelectric focusing (cIEF) and capillary zone electrophoresis (CZE) will help you understand your biotherapeutics and vaccines better to advance them with confidence. 

The PA 800 Plus system can help you with:

  • Monoclonal antibodies (mAbs) and mAb variants
    • Charge heterogeneity (cIEF)
    • Purity of mAbs and mAb variants (CE-SDS)
    • N-linked gylcan analysis
  • In vitro transcribed RNA (IVT RNA)
    • Purity and integrity of mRNA and other IVT RNA (CGE)
    • Purity and size of critical starting material (CGE)
  • Viral vectors
    • Capsid protein purity and ratios (CE-SDS)
    • Virus genome integrity (CGE)
    • Empty-full capsid ratio (CGE and CE-SDS)
    • Purity of critical starting material (CGE)
    • Residual host cell DNA (CGE)
  • Gene editing
    • Purity of guide RNA (CGE)
    • Purity and integrity of Cas9 mRNA (CGE)
PA 800 Plus Pharmaceutical Analysis System
Key features

Data quality

Achieve highest resolution with unmatched reproducibility using QC-trusted technology, including precise capillary temperature control.

Flexibility

Gain valuable insights into quality attributes of your biopharmaceuticals with intuitive kit-based assays including CE-SDS, CGE, cIEF, and CZE.

Sensitivity

Rest assured when sensitivity needs change. Switch between UV and laser-induced-fluorescence (LIF) detection within minutes.

Transferability

Confidently transfer methods from lab to lab or between CE systems from SCIEX.

Compatibility and QC

Meet data management needs with compatibility with the Empower Chromatography Data System (CDS) from Waters and the Thermo Scientific™ Chromeleon™ Chromatography Data System (CDS) as well as Windows10. Rely on technology trusted by US Pharmacopeia, such as the USP General Chapter 129.

Precision analytics for oligonucleotide, cell and gene therapy

As the technologies for manufacturing and analysis of gene therapy products continue to evolve, it’s important to keep up to date on growing industry trends and analytical advancements. This compendium can help advance your gene therapies and oligonucleotide therapeutics to the next level with the latest tools and methods.

Related applications

Glycan analysis

Manage development timelines with scalable N-linked glycan analysis solutions that rapidly identify therapeutic antibody glycosylation profiles.

Charge heterogeneity analysis

Take back your time with simple and transferrable methods to analyze mAb charge variants for identity and stability with high resolution.

Cell line analysis

Gain the advantage of knowledge up front, with rapid, sensitive and accurate CE-based cell line analysis strategies.

mRNA analysis

Achieve integrity, purity and encapsulation information of IVT RNAs and obtain insights into poly-A tail length and distribution with the highest data quality.

Plasmid DNA

Gain confidence in critical starting material from development to QC with trusted CGE technology to support the production of mAbs, mRNAs, viral vectors and more. 

Cell and gene therapy

Take charge of the purity and integrity of viral vectors while leveraging outstanding data quality. Overcome secondary structures and maximize your gene editing success. 

Empower your PA 800 Plus system with the SCIEX Empower Driver version 1.3

Take control of your PA 800 Plus system with Waters Empower 3 chromatography data software (CDS) for data integrity compliance. Reduce regulatory risk and maximize method transfer efficiency with the newly released SCIEX Empower Driver version 1.3.

Related products

RNA 9000 Purity & Integrity kit

Be covered from 50 to 9,000 nt and beyond for reliable integrity and purity assessment.

dsDNA 1000 kit

Achieve plasmid purity analysis and dsDNA sizing with QC-trusted data quality. (P/N 477410)

ssDNA 100-R kit

Move past limitations with single-base resolution for single-stranded oligonucleotides. (P/N 477480)

CZE Rapid Charge Variant Analysis kit

Achieve comprehensive characterization of charge variant-associated quality attributes throughout development.

Protein CE-SDS Purity Analysis kit

Get the quantitative data, automation and full method development flexibility you need for your purity analysis.

Fast Glycan Labeling and Analysis kit

Reclaim your time with rapidly glycan heterogeneity identification and profiling.

Resources

Filter by Type:

RNA 9000 purity and integrity kit methods

Characterization of lentiviral vectors using capillary electrophoresis platform technology webinar

High-throughput LNP-mRNA Integrity Profiling webinar

Proven answers for Protein, Vaccine and Nucleotide Characterization

High-throughput LNP-mRNA integrity profiling webinar

Masterclass LIVE: Characterization of engineered Cas9 protein and its post translational modifications - Webinar on-demand

Proven answers for protein, vaccine and gene therapy analysis webinar

Sample Preparation for the Fast Glycan Labeling and Analysis kit on the PA 800 Plus system video

Viral vector characterization: empty/full, transgene integrity and capsid protein analyses on a single platform webinar

Drug antibody ratio (ADC) calculations made easy and simple webinar

Genome integrity analysis of adeno-associated viruses (AAV) by genome sizing methodology webinar

How are CE methods being adapted to analyze new modalities webinar

Tips and Tricks for using the PA 800 Plus (JA) video

Best practices for using the PA 800 Plus with CE-SDS (JA) video

Peptide therapeutics analysis by Capillary Electrophoresis

Comprehensive method development for a wide size range of RNA

Pre-Assembled Cartridge flyer

Challenges with CE-SDS?

Low pH SDS sample buffer flyer (ZH)

ruo-mkt-07-14191-a-rna-kit-flyer_V1_08-23

CZE Rapid Charge Variant Analysis kit flyer (ZH)

CE Consumable Flyer

PA 800 Plus system start-up consumable groups flyer

PA 800 Plus system Empower driver notes de version (FR)

PA 800 Plus system Empower driver notas de la versión (ES)

PA 800 Plus system Empower driver 版本发布说明 (ZH)

PA 800 Plus system Empower driver リリースノート (JA)

PA 800 Plus system Empower driver note di rilascio (IT)

PA 800 Plus system Empower driver versionshinweise (DE)

PA 800 Plus system Empower driver release notes

PA 800 Plus system Empower driver user guide

PA 800 Plus system Empower driver user guide (DE)

PA 800 Plus system system maintenance guide (EN)

PA 800 Plus System Overview Guide (EN)

PA 800 Plus system Empower driver user guide (ES)

PA 800 Plus system software validation guide

PA 800 Plus system Empower driver user guide (IT)

PA 800 Plus system Empower driver user guide (JA)

PA 800 Plus system Empower driver user guide (ZH)

PA 800 Plus Pharmaceutical Analysis System - System Administration Guide

PA 800 Plus system Empower driver user guide (FR)

PA 800 Plus system IgG Purity and Heterogeneity Assay kit application guide

PA 800 Plus system RNA 9000 Purity & Integrityキット アプリケーションガイド

PA 800 Plus system LIFluor™ EnhanCE dsDNA 1000 Dye application guide (JA)

PA 800 Plus system Fast Glycan Labeling and Analysis kit application guide

PA 800 Plus system IgG Purity and Heterogeneity Assay kit application guide (JA)

PA 800 Plus system IgG Purity and Heterogeneity Assay kit application guide (ZH)

PA 800 Plus system SDS-MW Analysis kit application guide

PA 800 Plus system ssDNA 100-R kit application guide (ZH)

PA 800 Plus system dsDNA 1000 kit application guide

PA 800 Plus system CZE Rapid Charge Variant Analysis kit application guide (ZH)

PA 800 Plus system dsDNA 1000 kit application guide (JA)

PA 800 Plus system Capillary Isoelectric Focusing (cIEF) Analysis kit application guide

PA 800 Plus system ssDNA 100-R kit application guide

PA 800 Plus system Capillary Isoelectric Focusing (cIEF) Analysis kit application guide (JA)

PA 800 Plus system SDS-MW Analysis kit application guide (JA)

PA 800 Plus system RNA 9000 Purity & Integrity 试剂盒 应用指南

PA 800 Plus system LIFluor™ EnhanCE dsDNA 1000 Dye application guide (ZH)

PA 800 Plus system CZE Rapid Charge Variant Analysis kit application guide

PA 800 Plus system SDS-MW Analysis kit application guide (ZH)

PA 800 Plus system LIFluor™ EnhanCE dsDNA 1000 Dye application guide

PA 800 Plus system ssDNA 100-R kit application guide (JA)

PA 800 Plus system Capillary Isoelectric Focusing (cIEF) Analysis kit application guide (ZH)

PA 800 Plus system CZE Rapid Charge Variant Analysis kit application guide (JA)

PA 800 Plus system RNA 9000 Purity and Integrity kit application guide

PA 800 Plus system dsDNA 1000 kit application guide (ZH)

CE Grade Water flyer

CE instrument maintenance flyer

PA 800 Plus system brochure (ES)

Breaking through boundarieswith CRISPR gene editing

SCIEX solutions for LNP-based genetic medicines brochure

CE-SDS training flyer

CE Training Overview 2021

Capillary electrophoresis Windows 10 flyer

Empower Your PA 800 Plus with Waters Empower3 Enterprise Software

Fast Glycan labeling and analysis kit flyer

Fast Glycan Labeling and Analysis kit flyer

Capillary electrophoresis consulting flyer

Capillary Electrophoresis kit brochure

Low pH phosphate SDS sample buffer flyer (ZH)

LC-MS/MS 技术平台

Capillary electrophoresis solutions for DNA/mRNA vaccines flyer (ZH)

PA 800 Plus system Empower driver flyer (ZH)

SCIEX Capillary Electrophoresis Consumables flyer

Low pH SDS sample buffer flyer

SCIEX solutions for gene therapy and oligonucleotide compendium

CE Training Overview DE 2021

CE consumables and reagents catalog

Capillary electrophoresis training course flyer

CZE Rapid Charge Variant Analysis kit flyer

A holistic approach to understanding cIEF poster

Fully automated sample preparation with ultrafast N-glycosylation analysis of therapeutic antibodies poster

Native state charge variant analysis of commercialized monoclonal antibodies poster

A sensitive and robust plasmid analysis method by capillary electrophoresis-laser induced fluorescence (Pfizer and SCIEX) poster

CZE Method

CZE Capillary Conditioning

CZE Shutdown

CZE Rapid Charge Variant Analysis kit methods

CZE Analysis

Low-level quantitation of impurities in bispecific proteins using CE-SDS with LIF detection

High-precision lentivirus titer determination and protein profiling

Size distribution analysis of residual host cell DNA fragments in lentivirus by CGE-LIF

Development of purity analysis methods for synthetic prime editing guide RNAs (pegRNAs) with high-level secondary structures for prime editing research applications

Rapid CZE analysis of erythropoietin variants

Sensitive impurity analysis of AAV capsid proteins by CE using Chromeo P503 fluorescent (ES)

Capillary electrophoresis in quality control: Part I: Application for therapeutic proteins

A Robust cIEF Method: Intermediate Precision

Assessing glycosimilarity of biotherapeutics

Simple, fast and robust method for plasmid purity testing and degradation monitoring

High efficiency evaporative fluorophore labeling of glycans

Achieving robust cIEF analysis of monoclonal antibodies while increasing capillary run-life and maintaining high resolution and reproducibility

Accurate analysis of double stranded DNA over an extended size range

Assay of IgG purity and heterogeneity using high-resolution sodium dodecyl sulfate capillary gel electrophoresis

Sensitive AAV capsid protein impurity analysis by CE using P503 dye

Preparation scale-up of complex biological samples for deep N-glycomic analysis by CE-LIF and CESI-MS

IgG purity/heterogeneity and SDS-MW assays with 96-well plate adaption

Purity analysis of adeno-associated virus (AAV) capsid proteins using CE-SDS method

Native state charge variant analysis of commercialized monoclonal antibodies in minutes

RNA Analysis for CRISPR by capillary electrophoresis with laser-induced fluorescence detection

Genome sizing methodology for genome integrity analysis of adeno-associated viruses (AAV)

Automation of CE-SDS for IgG purity/heterogeniety

Comparative characterization of the Fc domain N-glycosylation in monoclonal antibody and fusion protein therapeutics

Ultrafast Analysis of Human Milk Oligosaccharides (HMOs)

Capillary electrophoresis in quality control: Part II: CE-SDS: Method development and robustness

Separation of recombinant human erythropoietin (rhEPO) using the European Pharmacopoeia method on the PA 800 plus system

Simplifying CE-SDS data processing with mineral oil

Velocity-corrected area calculation: SCEX PA 800 plus system Empower driver version 1.3 vs. 32 Karat software

Identification of System Parameters Critical for High-Performance cIEF

Fast glycan sequencing using a fully automated carbohydrate sequencer

Purity analysis of adeno-associated virus (AAV) capsid proteins using CE-LIF technology

Evaluation of the glycosimilarity of biotherapeutics (ES)

Optimize non-reduced CE-SDS analysis with the SCIEX low pH SDS sample buffer

SDS-MW calibration and molecular weight estimation using the SCIEX PA 800 Plus Empower driver version 1.3

Optimization of a robust and sensitive capillary electrophoresis laser induced flourescence method for monitoring plasmid stability and purity

High-Resolution cIEF of Therapeutic Monoclonal Antibodies

A Series of Collaborations Between Various Pharmaceutical Companies and Regulatory Authorities Using CE

A single analytical platform for glycan analysis, charge heterogeneity, and purity determination of the NIST mAb

Rapid CZE analysis of erythropoietin variants (ZH)

Heterogeneity analysis of cysteine-linked antibody-drug conjugate by CE method (ZH)

Analyzing the average degree of substitution of betadex sulfobutyl ether sodium by capillary electrophoresis (ZH)

Analysis of purity and isoelectric points of HPV by capillary electrophoresis (ZH)

Purity analysis of CircRNA vaccine by CGE-LIF method (ZH)

十六烷基磺酸钠-毛细管凝胶电泳法用于双抗的纯度分析

Study on the stability of RNA Analysis by neutral capillary combined with RNA 9000 Kit (ZH)

Analysis of Purity and Integrity of mRNA Vaccine by Capillary Gel Electrophoresis (ZH)

Size analysis of residual host cell DNA in Lentivirus by CGE-LIF

Highly sensitive CE-SDS-LIF purity analysis of T7 RNA polymerase (ZH)

Purity analysis of oligonucleotides by capillary gel electrophoresis (ZH)

Analysis of Poly A tail distribution of mRNA by capillary gel electrophoresis (ZH)

High Throughput Detection of IgG Purity by Using Quick Rinse CE-SDS Separation Method

CGE-LIF方法分析不同工艺阶段狂犬疫苗中宿主残留DNA的片段大小分布

Purity analysis of SgRNA by capillary gel electrophoresis (ZH)

Identification and quantitative analysis of impurity E in glutathione by capillary electrophoresis (ZH)

Rapid purity analysis of plasmid using neutral coated capillary in CGE-LIF method (ZH)

Analysis of size variants and isoelectric point of recombinant human serum albumin by capillary electrophoresis (ZH)

Size analysis of residual host cell DNA in Recombinant protein vaccine by CGE-LIF (ZH)

Determination of free carrier proteins in polysaccharideprotein conjugate vaccines by capillary micellar electrokinetic chromatography (ZH)

Purity analysis of monoclonal antibodies (5-TAMRA labeling) by CE-SDS-LIF (ZH)

SCIEX CE solutions in China Pharmacopoeia (ZH)

Determination of P-carboxybenzaldehyde and P-methyl benzoic acid in P-terephthalic acid by capillary electrophoresis (ZH)

Quality control of raw materials of diagnostic reagent in vitro by capillary electrophoresis (ZH)

Quantification of whey protein content in infant formula by CE-SDS (ZH)

Multi-laboratory validation for the purity analysis of protein products in CE-SDS method using CESI 8000 Plus (ZH)

The determination of α-lactalbumin and β-lactoglobulin in dairy by capillary zone electrophoresis (ZH)

Purity analysis of MRNA vaccine by using CGE-LIF (ZH)

Comparation the N-Glycan of different sources recombinant human erythropoietin by using capillary electrophoresis with laser-induced fluorescence detector (ZH)

The determination of lactoferrin in dairy by capillary zone electrophoresis (ZH)

Isoelectric points analysis of LNP encapsulated mRNA by cIEF (ZH)

Learning Center 
Installing the LIF aperture and probe guide/Stabilizer step-by-step Video GuideWatch
Cartridge removal, rebuild and reinstallation step-by-step video guideWatch
Change the coolant tubing step-by-step video guideWatch
Change a detector step-by-step video guideWatch
Capillary removal step-by-step video guideWatch
Capillary storage step-by-step video guideWatch
Fast Glycan softwareDownload
How to maximize your capillary life flyerDownload