Gain better insights into impurities and biotransformations

Driven by MS and MS/MS enhanced with electron activated dissociation (EAD) and extensive libraries, Molecule Profiler software delivers highly accurate, flexible workflows for structurally elucidating a wide variety of molecules.

Help get the answers you need about molecule impurities, biotransformations and metabolites faster and with more confidence than ever before.

Molecule Profiler software is built into the architecture of SCIEX OS mass spectrometry software to support a seamless acquisition and data analysis experience.


Integrated for greater ease

When you have many different software products, you generally need to jump around from application to application, which takes time and increases training requirements.

Molecule Profiler software is a fully integrated application within SCIEX OS software. Easily multitask with other functions in SCIEX OS software without the need to move data around.


Flexibility across molecule types

Why have a separate piece of software for every type of molecule you develop?

Molecule Profiler software is a single tool that can provide insights about impurities and biotransformations across molecule classes, including lipids, therapeutic oligonucleotides, small molecule drugs, peptide therapeutics and antibody-drug conjugates (ADCs).

From characterizing impurities for ensuring quality to quickly turning around biotransformation and metabolite identification information to optimize development, Molecule Profiler software is the tool for you. It is equipped with extensive libraries for synthetic impurities along with biotransformation information and the ability to process collision induced dissociation (CID) and electron activated dissociation (EAD) data. Identification of your unknown analytes just became easier.

Confidence through MS/MS

Many impurities and biotransformations result in isoelemental species that an MS-only workflow just cannot solve.

With the capability to incorporate UV, MS and MS/MS information, you can get clear and unambiguous results that help give you complete confidence.


Get answers, faster

Larger and more complex molecules—such as lipids, oligonucleotides and peptides—can produce very complex MS/MS data.

The powerful MS/MS engine in Molecule Profiler software can reduce the time to an answer from days down to hours.

Easily build processing queues with the ability to choose multiple processing methods and controls. Each result analysis can be completed in just a few minutes.

Structural depth with confidence in lipids

Lipid raw materials and lipid nanoparticles (LNPs) must be fully characterized to differentiate impurities, such as oxidation from ionizable lipids, which can affect product safety and efficacy.

With the ability to automatically process EAD and CID data, you can streamline workflows to help get reliable answers faster and ensure the quality of the nucleic acid, including mRNA, in LNPs.


Confidence in your oligonucleotides

Side reactions during synthesis can lead to enormous numbers of impurities within oligonucleotide products. Furthermore, biotransformations are often complex given the high variability of sequence modifications. Quick identification of species in a product or sample is crucial to accelerating development.

Choose from off-the-shelf libraries for oligonucleotide impurities and biotransformations to get a head start and amend as needed for full flexibility.

SCIEX has worked with our partners at Integrated DNA Technologies (IDT) to create a comprehensive library to help ensure your sequence is right.


Small molecule metabolite identification with speed and ease

Automate your metabolite identification with confident metabolite structure assignments using both CID and EAD data, helping to save time and money in your laboratory.



Molecule Profiler software is compatible with SCIEX high resolution mass spectrometers


ZenoTOF 7600 system

This high-resolution mass spectrometer provides comprehensive data with new innovations that have never been seen in an accurate mass spectrometer. The introduction of electron activated dissociation (EAD) fragmentation and the Zeno trap pave the way for precise and accurate MS and MS/MS data.

X500 B and X500R QTOF systems

With simple workflows, robust hardware, sensitivity and precision, the X500B and X500R QTOF systems are the first LC-MS/MS systems designed for both characterization and quantitation.