SCIEX OS software brings efficiency, depth and new potential to your
research
SCIEX OS is quicker than previous
operating systems. The time between sample injections has been
significantly reduced to just a couple of seconds.
Over the duration of a large batch the
time saving is vast, consider that
over a week, month or a year. SCIEX OS will improve your analytical
throughput.
Additional new features...
Version feature matrix
View a list of all the features that were added to each version of SCIEX OS software.
POWER UP YOUR LABORATORY
The Power of Precision.
Sciex OS Software 3.1
Engineered to do more.
Faster.
SCIEX OS software brings efficiency, depth and new potential to your
research
SCIEX OS is quicker than
previous operating systems. The time between sample
injections has been
significantly reduced to just a couple of seconds.
Over the duration of a large
batch the time saving is vast, consider that
over a week, month or a year. SCIEX OS will improve your
analytical throughput.
Additional new features...
Multiple
MS and LC methods
SCIEX OS now supports Open Multiple methods in MS and LC
Method workspace. Using the View menu, the
user can change the arrangement of the methods to
tabbed, vertical tiled, horizontal tiled, or
floating view.
LC Driver
Update
New LC driver has been incorporated into SCIEX OS that
will support microflow gradient separations
using the Mikros system.
Zeno SWATH DIA integration
SCIEX OS and the SCIEX 7600 system are fully integrated
to run Zeno SWATH DIA. This brand-new
experiment type brings better insights with significant
sensitivity gains of lesser abundant ions
enabling a new level of completeness and certainty to
biomarker research.
ExionLC
2.0 enhancement
SCIEX OS now supports the use of column switching vales.
Up to 2 valves can be supported, either
multi-position or2-position valves in any combination.
Switching valve function during acquisition
is controlled in the LC Method, however switching valve
function can also be controlled using Device
control during equilibration.
Capabilities
Acquisition
Processing
Processing
Management
Management
Acquisition
The Batch workspace is used to create and submit samples
This is where you enter details about
your samples, including the mass spectrometry and liquid
chromatography methods and the autosampler values, such as rack
position, plate type, vial position and sample injection volume.
You can also indicate the processing method to use and where to
save the results file in the directory. Building a batch is
simple and straightforward, and any existing Analyst software
methods can be directly imported into SCIEX OS software.
Other features available in the Batch
workspace include auto-calibrate functionality, which enables
accurate mass systems to select the right type of calibration
solution for your method and the plate layout of the autosampler
rack. Previously saved batches can also be reopened, and the
Manage tab can be used for adding rows to your batch. When your
details are entered, the batch is ready to go and you can hit
submit.
Top tip...
Acquire data overnight, and have it waiting for
you in the morning. By incorporating your processing method into
your batch, once a sample is finished acquiring, it will start
processing automatically. When you return to work, the data is
ready for your review, saving time and getting to the results
faster.
Watch the progress of your
analysis in real time
After you hit submit in the Batch
workspace, you can view the progress of your analysis in the
Queue workspace. The acquisition status is displayed, so you can
quickly see that your samples are running smoothly. The
estimated start time allows you to forecast when the analysis
will be complete.
The Queue workspace displays many of the
same details from the Batch workspace, such as MS and LC
methods. You have the power to start and stop the queue from
here, should you wish to make changes to your batch.
Save time and reduce sample loss
Decision rules functionality allows for immediate detection of
failures and implementation of corrective action based on criteria
that you establish. This non-subjective decision making adapts to
changing conditions during analysis.
The decision rules functionality continually checks against
customized criteria. With decision rules, you don't have to
wait for acquisition, data processing and data review to discover
failures and take action.
Top tip...
Create your own rules to address failures when
they occur. With decision rules, you are able to associate your
processing method in the batch and apply flagging rules to make
real-time decisions during data acquisition, which saves time
and reduces sample loss.
Create new MS methods based on
the type of workflow you want to build
In the MS Method workspace, you can
create a standard MRM or MRMHR method, depending on
whether you are operating a SCIEX Triple Quad system or an
accurate mass instrument. If you are running a SCIEX accurate
mass instrument, you might want to create a SWATH acquisition
method. Guided method creators are available to assist you in
developing new methods for new analytes you want to analyze.
Source parameters (such as source gases,
curtain gas and temperature settings) for the Turbo V ion source
and the OptiFlow Pro ion source can be configured here.
The Experiment section is for selecting
the type of experiment to run, such as TOF MS, MRM and
MRMHR. You can select multiple experiments for your
analysis, so your system can acquire even more data for you.
Automated compound optimization
Whether it's an infusion, flow injection, on-column or
MRM3 approach, the automated compound optimization
feature for quantification is simple, flexible and completely
automated. There are also options for choosing optimal parameters
such as signal-to-noise (S/N) ratio or intensity requirements.
Scheduled MRM
Scheduled MRM (sMRM) helps drive the accuracy and precision of your
mass spectrometer. sMRM accounts for any potential retention time
(RT) drifts, and all RTs can be updated with a single click. sMRM
also has functionality to call out single dwell time instances so
you can maximize the abundance of low-intensity ions. In addition,
interactive sMRM plots dynamically update with any changes in the
sMRM method.
Top tip...
Easily transfer acquisition methods from Analyst
software to SCIEX OS software. This saves time and helps prevent
transcription errors. Convert your acquisition method directly
in the SCIEX OS MS Method workspace and your method transfer is
done!
Build separate LC methods
SCIEX OS software enables you to build
separate liquid chromatography methods. The information
displayed in the LC Method workspace will depend on the LC
configuration you select for your analysis. Here, you can input
all the details regarding flow rates, autosampler conditions,
column oven temperature controls and potential wavelength data
for photodiode array detector (PDA) wavelengths. You can also
adjust any other settings you may need, such as executing an
auto-purge before analysis.
Top tip...
Use one LC method for multiple MS methods to
reduce method development time, explore different MS methods and
simplifying method management.
Smarter, faster and simple statistical analysis software
A data visualization tool designed for scientists who wish to visualize their data in terms of sample groupings and apply statistics in order to gain valuable insight into any trends within their mass spectral data. MarkerView is unique in that SCIEX users can explore statistical correlations with direct connections back to the raw data. This allows them to find meaningful relationships much more quickly. Particularly useful for metabolomics, lipidomics, proteomics, food authenticity and water testing.
Perform several tuning
procedures on your mass spectrometer
The Tuning Procedures drop-down menu
shows specific options for you instrument. You can use the
detector optimization tool to optimize the detector voltage if
you notice the sensitivity of the system seems low.
Automated tuning
SCIEX OS software enables automated tuning for the SCIEX Triple Quad
7500 system and the X500 series QTOF systems by calibrating all
scans across all modes for added confidence that your system is
ready to use with fast, easy and simple tuning.
Your instrument will be calibrated correctly with built-in
acceptance criteria for a higher first-time success rate, saving you
a significant amount of time.
Faster and easier tuning
Easy troubleshooting
Increased calibration confidence
A single calibrant for both positive and negative mode means:
No calibrant contamination
No changing solutions
One 1 optimization procedure
Top tip...
Use one LC method for multiple MS methods to
reduce method development time, explore different MS methods and
simplifying method management.
Open all your acquired data files in the Explorer workspace
The navigation tools in the Explorer
workspace allow you to quickly move through the samples for an
overview of your data. You can view the data in several ways
depending on your preference.
Show tab: allows you to view the total ion chromatogram
(TIC), extracted ion chromatogram (XIC) and IDA explorer
Graph tab: shows different options for displaying your data
and allows you to customize the labels in the graph
Process tab: allows you to apply settings such as baseline
smoothing and specify how your data will be processed
Bio Tool Kit: opens up a section that enables the peptide
sequencing
Top tip...
Save time when you need to dig deeper into the
raw data, with a click of the mouse. PeakView software is
wrapped inside SCIEX OS software in the Explorer workspace.
Easily launch the Explore workspace from the peak review pane in
Analytics in one click!
Spend less time digging for answers
Review by exception
Spend less time digging for answers. Only
review data of interest with flag-based labelling and filtering
tools.
Support of “IF” statements
SCIEX OS software has the ability to support “IF” statements for
your analysis queries. There is functionality to execute
calculations within the “IF” statement. “IF” statements can be built
into the flagging rules when the outcome is a numeric value. Some of
the data analysis you wish to conduct may be complex, therefore
there is no limitation on the formula size of your query. Nested
“IF” statements are also supported, and they can be packaged into a
.frml file format and shared.
Top tip...
Import processing methods into SCIEX OS software.
Your Analyst software or MultiQuant
software processing methods can be imported directly into SCIEX
OS software.
Achieve better
insights into biotransformations and impurities
Driven by MS and MS/MS data analysis
coupled with extensive libraries, Molecule Profiler software
delivers highly accurate and flexible workflows for determining
impurities and biotransformations for a wide variety of
therapeutic molecules.
Molecule Profiler is fully integrated as
part of SCIEX OS, and has the same look and feel. Easily
multitask with other functions in SCIEX OS. And, there is no
need to move data around.
Customizable to meet the
needs of both research and regulatory requirements
The Configuration workspace displays
active devices, allowing you to activate or deactivate the
hardware in your workflow.
The Configuration workspace also provides the ability to add devices
you may need or edit the configuration of your instruments. Within
the workspace, you can adjust settings for queue management, such as
maximum idle time allowed before the system goes into standby and
the maximum number of samples allowed. There are also rule settings
that advise users on what to do when a sample is missing, for
example. If you are operating one of the X500 series QTOF
instruments, you can specify calibration settings and what the
system should do if there is a calibration failure.
Project tab: specify the project folders or root directories on
your laboratory's network that will store your acquired
data'
User Management tab: assign user roles, such as administrator,
method developer, analyst and reviewer'
Roles tab: assign permissions for each role'
Security tab: set the security parameters, such as screen lock
times, auto logoff times and logon failure parameters'
Licenses tab: view the current licenses that are available, and
install additional licenses or add-ons if needed'
LIMS tab: connect to a laboratory information management system
(LIMS) server by entering its URL (note that this connection is
not necessary for a Watson LIMS, which is compatible with SCIEX
OS software for direct data transfer)'
With the most recent version of SCIEX OS software, users can now
check to see if their software is up to date'
Top tip...
Easily set up and manage multiple devices on one
mass spectrometer. You can add devices individually and simply
check the box next to the device you want to activate.
Import a library for use as part
of your workflow
The Library workspace is used to import a
library that you would like to use as part of your workflow.
Libraries provide additional confirmation and assurances for
confirm your data acquisitions. You can import a LibraryView
software package or your own custom library.
During this process, you can select which
compounds you would like to include in your processing. You may
want to include every compound in the SCIEX All-in-One HR-MS/MS
library, for instance, or just extract the compounds that are
crucial to your experiment.
Top tip...
Easily add new compounds to MS/MS libraries
directly from the peak review pane, making library building a
breeze!
View the key instances
occurring in your system
The Event Log workspace shows you useful
diagnostic information and events happening within SCIEX OS
software. Within this workspace, you can archive a log at your
specific intervals. You can also open previously archived event
logs here, so you can dig into any of the information that may
be of use.
Filter events depending on what you want to investigate
Segment the log based on the device or workspace
Customize the view to find just the events you want to
interrogate
Top tip...
All events, all in one place. You can see and
export all events, or you can select devices or workspaces to
see specific events.
Achieve data integrity
across every run, on every system
From compliant routine analyses to flexible research workflows, the intuitive Audit Trail workspace ensures full traceability and accountability. It includes built-in data integrity features that allow you to tailor each functionality specifically to your lab's compliance and data security requirements.
Fully compliant with GxP and 21 CFR Part 11
Configurable security settings
Electronic signatures and audit trails
Customizable security management
End-to-end audit trail
Always be ready for your next audit
SCIEX integrated compliance services include integrated analytical
instrument qualification and software validation packages that cover
your complete SCIEX system workflow.
All events, all in one place. You can see and
export all events, or you can select devices or workspaces to
see specific events.
More efficient
Increase your productivity. Consistently deliver high-quality, actionable data from your
mass
spectrometry workflows with easy-to-learn SCIEX OS software.
Improved usability
Create an integrated experience across any and all of your SCIEX instruments (including
SCIEX Triple Quad, QTRAP and QTOF systems).
Greater integrity
The accuracy, precision and stability of SCIEX OS software helps ensure your data
quality—batch after batch and throughout every stage of your MS workflow—remains
uncompromised.
STMRM: SCOUT TRIGGERED MRM
Increase efficiency and reduce method maintenance
SCIEX OS software is the platform for an exciting, data-rich workflow called
scout triggered MRM (stMRM). Intelligent monitoring of the designated marker
analytes increases efficiency and reduces the demand for method maintenance. An
stMRM license unlocks your SCIEX Triple Quad system to obtain better-quality
data across vast screening workflows.
With standard Scheduled MRM (sMRM), you define retention time
windows for each transition in your
method. Instead of RT windows, Scout triggered MRM uses
exogenously spiked compounds, such as an
internal standard or marker compound to trigger the acquisition
of groups of dependent MRMs.
Benefits
Easy method maintainance
Employ stMRM to stagger marker compounds across the run and
trigger groups of dependent
MRMs
without
using RT.
Simple method transfer
With no dependence on RT, stMRM workflows are not affected by
changing LC conditions like
a
standard sMRM method.
Central administrator console
Control, manage and audit
Laboratories with multiple instruments can now use the SCIEX OS
software Central Administrator Console (CAC) to create and manage projects.
Now available in 9
different languages不同的语言idiomas diferentes다른 언어들différentes languesidiomas diferentesverschiedene Sprachenlingue differenti異なる言語
Confidently collaborate with colleagues without
language constraints
SCIEX OS software is now available in Simplified Chinese, Japanese,
Korean, German, Italian, French,
Spanish, Portuguese and English.
Translate the user interface by selecting your preferred language in the Configuration workspace. This allows you to more easily communicate with internal laboratories, while providing flexibility for global collaboration and to seize new opportunities. Continuity and compliance can be maintained with an option for the audit trail to remain in English.
Compatibility
Power up your SCIEX ecosystem
Echo MS
The Echo® MS system powered by SCIEX OS software. Automated
processing and
enhanced data
visualization tools enable scalability of ultra-high throughput workflows such as
drug pipeline
development, while maintaining the quality and integrity of the results.
QTRAP and QTOF
SCIEX OS software powers up all targeted, non-targeted and suspect screening
workflows analyzed with
your SCIEX QTRAP, ZenoTOF, TripleTOF and X500 QTOF series instruments. Automated custom flagging and
filtering tools enable rapid data review and real-time decision making. All with
high levels of
confidence.
Triple Quad
SCIEX OS software is the complete software platform for the SCIEX Triple
Quad 7500,
6500+
series,
5500+
series and 4500
systems. With its automated tools simplifying peak finding and integration, and
calibration curve review, SCIEX OS software helps you reach new levels of precision
across all your
quantitative workflows.
Licenses
OS
Acquisition, control and quantification and qualification processing.
Acquisition
Network acquisition
Qualitative processing
OS-Q
Quantification and qualification processing.
Qualitative processing
Quantitative processing
OS-MQ
Optimized quantification processing.
Quantitative processing
Mixed-mode security setting
OS features
Acquisition
Network acquisition
Qualitative processing*
Quantitative processing
LibraryView software*
Mixed-mode security setting
Watson LIMS results transfer
*Excluding Triple Quad 4500, 5500+ and
6500+
Add-on modules
Separate
license required
stMRM algorithm
Central Administration Console
ChemSpider*
Bio Tool kit
21 CFR Part 11 tools
Intact quantification workflow
OS-Q features
Qualitative processing
Quantitative processing
LibraryView software
Mixed-mode security setting
Watson LIMS results transfer
Add-on modules
Separate
license required
stMRM algorithm
Central Administration Console
ChemSpider
Bio Tool kit
21 CFR Part 11 tools
Intact quantification workflow
OS-MQ features
Quantitative processing
Mixed-mode security setting
Watson LIMS results transfer
Add-on modules
Separate
license required
stMRM algorithm
Central Administration Console
ChemSpider
Bio Tool kit
21 CFR Part 11 tools
Intact quantification workflow
OS compatibility
ZenoTOF 7600 system
Triple Quad systems:
7500
6500+, 6500
5500+, 5500
4500
X500 series QTOF systems
OS-Q compatibility
TripleTOF systems:
ZenoTOF 7600
TripleTOF 6600+
QTRAP systems:
6500+
5500+
4500
OS-MQ compatibility
Triple Quad systems:
7500
6500+, 6500
5500+, 5500
4500
TripleTOF systems:
ZenoTOF 7600
TripleTOF 6600+
QTRAP systems:
6500+
5500+
4500
Support
Keeping up to date
SCIEX innovation is driven by customer needs and collaboration. Because of
this, SCIEX will always improve and evolve its mass spectrometry software. Since the launch
of SCIEX OS software in 2015, there have been several advancements in testing capabilities,
functionality and productivity.
Starter
Additional
PlusLegacy
AdvanceAssist
Software upgrades (version 3.0 to 3.1) for eligible software
Yes
No
Yes
No
Software updates (includes point releases and hotfixes)
Yes
Yes
Yes
Yes
Access to premium Learning Hub and knowledge base content online
Yes
Yes
Yes
Yes
Priority access to remote software support (during business hours) via
telephone and SCIEX Now
Yes
Yes
Yes
Yes
Discounted rates on selected software licenses and related software services
Yes
Yes
Yes
Yes
Discounted rates for validation and compliance services for easier upgrades
Incorporate electronic audit trails, electronic signatures and detailed security
configurations
to support GxP and 21 CFR Part 11 regulations. SCIEX OS software offers the
flexibility to
tailor and deploy security policies that help you meet the requirements of your
laboratory.
Software downloads
Existing users of SCIEX OS software can download the latest updates here.
License activation
Follow this link to activate a new SCIEX OS software license.
User manuals
The latest operating manuals are available here for your reference.
EULAs
Here is a link to all the relevant end-user licence agreements for your version
of SCIEX OS
software.
Advantages of SCIEX OS software over Analyst software
"SCIEX OS software improved our workflow notably due to the helpful
additional
features and the ability to work with the LC-MS holistically in one software
without
having to jump in and out of programs."
Sarah-Jane Pierre
Senior Scientist - Toxicology // Australian Clinical Labs
01 /
05
"In new innovations, software is key, as the software enables the creation of
results. Software that integrates data acquisition, processing, interrogation and
reporting gives added value in terms of efficiency with which these results can be
generated"
Lieve Dillen, Senior Principal Scientist
Assay Development and Analytical Support Development Bioanalysis Group Janssen R&D, Belgium
02 /
05
"We are very glad to have made the transition to SCIEX OS software for
acquisition on our 6500+ system to come in line with our two 7500 systems.
This has made training easier for the team as they have fewer software
platforms to learn, which has made a significant improvement to our
workflow. No more robocopy of data from the Analyst software file structure
to the SCIEX OS software file structure for processing."
Sam Mallard, Senior Analytical Instrument Chemist
Australian Superintendence Company
03 /
05
"Moving forward, labs will need to consider the complexity of the science that they are using for their toxicology screening. Streamlined workflows and efficient software play an extremely important role in achieving that."
Alex Krotulski, Program Manager
NPS Discovery // CFSRE // Philadelphia // Pennsylvania // US
04 /
05
"It's a huge leap forward in innovation, just to make mass spec simpler and more accessible to people. SCIEX OS has enabled anyone to walk up to the system and run their intact mass samples."
Rachel Rowlinson
Specialist in Protein Mass Spectrometry // Peak Proteins, UK
