Version feature matrix
View a list of all the features that were added to each version of SCIEX OS software.
Advantages of SCIEX OS software
Discover the capabilities you gain when you upgrade from Analyst software.
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SCIEX OS is quicker than previous operating systems. The time between sample injections has been significantly reduced to just a couple of seconds.
Over the duration of a large batch the time saving is vast, consider that over a week, month or a year. SCIEX OS will improve your analytical throughput.
View a list of all the features that were added to each version of SCIEX OS software.
Discover the capabilities you gain when you upgrade from Analyst software.
SCIEX OS is quicker than previous operating systems. The time between sample injections has been significantly reduced to just a couple of seconds.
Over the duration of a large batch the time saving is vast, consider that over a week, month or a year. SCIEX OS will improve your analytical throughput.
SCIEX OS now supports Open Multiple methods in MS and LC Method workspace. Using the View menu, the user can change the arrangement of the methods to tabbed, vertical tiled, horizontal tiled, or floating view.
New LC driver has been incorporated into SCIEX OS that will support microflow gradient separations using the Mikros system.
SCIEX OS and the SCIEX 7600 system are fully integrated to run Zeno SWATH DIA. This brand-new experiment type brings better insights with significant sensitivity gains of lesser abundant ions enabling a new level of completeness and certainty to biomarker research.
SCIEX OS now supports the use of column switching vales. Up to 2 valves can be supported, either multi-position or2-position valves in any combination. Switching valve function during acquisition is controlled in the LC Method, however switching valve function can also be controlled using Device control during equilibration.
This is where you enter details about your samples, including the mass spectrometry and liquid chromatography methods and the autosampler values, such as rack position, plate type, vial position and sample injection volume. You can also indicate the processing method to use and where to save the results file in the directory. Building a batch is simple and straightforward, and any existing Analyst software methods can be directly imported into SCIEX OS software.
Other features available in the Batch workspace include auto-calibrate functionality, which enables accurate mass systems to select the right type of calibration solution for your method and the plate layout of the autosampler rack. Previously saved batches can also be reopened, and the Manage tab can be used for adding rows to your batch. When your details are entered, the batch is ready to go and you can hit submit.
Acquire data overnight, and have it waiting for you in the morning. By incorporating your processing method into your batch, once a sample is finished acquiring, it will start processing automatically. When you return to work, the data is ready for your review, saving time and getting to the results faster.
After you hit submit in the Batch workspace, you can view the progress of your analysis in the Queue workspace. The acquisition status is displayed, so you can quickly see that your samples are running smoothly. The estimated start time allows you to forecast when the analysis will be complete.
The Queue workspace displays many of the same details from the Batch workspace, such as MS and LC methods. You have the power to start and stop the queue from here, should you wish to make changes to your batch.
Decision rules functionality allows for immediate detection of failures and implementation of corrective action based on criteria that you establish. This non-subjective decision making adapts to changing conditions during analysis.
The decision rules functionality continually checks against customized criteria. With decision rules, you don't have to wait for acquisition, data processing and data review to discover failures and take action.
Create your own rules to address failures when they occur. With decision rules, you are able to associate your processing method in the batch and apply flagging rules to make real-time decisions during data acquisition, which saves time and reduces sample loss.
In the MS Method workspace, you can create a standard MRM or MRMHR method, depending on whether you are operating a SCIEX Triple Quad system or an accurate mass instrument. If you are running a SCIEX accurate mass instrument, you might want to create a SWATH acquisition method. Guided method creators are available to assist you in developing new methods for new analytes you want to analyze.
Source parameters (such as source gases, curtain gas and temperature settings) for the Turbo V ion source and the OptiFlow Pro ion source can be configured here.
The Experiment section is for selecting the type of experiment to run, such as TOF MS, MRM and MRMHR. You can select multiple experiments for your analysis, so your system can acquire even more data for you.
Whether it's an infusion, flow injection, on-column or MRM3 approach, the automated compound optimization feature for quantification is simple, flexible and completely automated. There are also options for choosing optimal parameters such as signal-to-noise (S/N) ratio or intensity requirements.
Scheduled MRM (sMRM) helps drive the accuracy and precision of your mass spectrometer. sMRM accounts for any potential retention time (RT) drifts, and all RTs can be updated with a single click. sMRM also has functionality to call out single dwell time instances so you can maximize the abundance of low-intensity ions. In addition, interactive sMRM plots dynamically update with any changes in the sMRM method.
Easily transfer acquisition methods from Analyst software to SCIEX OS software. This saves time and helps prevent transcription errors. Convert your acquisition method directly in the SCIEX OS MS Method workspace and your method transfer is done!
SCIEX OS software enables you to build separate liquid chromatography methods. The information displayed in the LC Method workspace will depend on the LC configuration you select for your analysis. Here, you can input all the details regarding flow rates, autosampler conditions, column oven temperature controls and potential wavelength data for photodiode array detector (PDA) wavelengths. You can also adjust any other settings you may need, such as executing an auto-purge before analysis.
Use one LC method for multiple MS methods to reduce method development time, explore different MS methods and simplifying method management.
A data visualization tool designed for scientists who wish to visualize their data in terms of sample groupings and apply statistics in order to gain valuable insight into any trends within their mass spectral data. MarkerView is unique in that SCIEX users can explore statistical correlations with direct connections back to the raw data. This allows them to find meaningful relationships much more quickly. Particularly useful for metabolomics, lipidomics, proteomics, food authenticity and water testing.
The Tuning Procedures drop-down menu shows specific options for you instrument. You can use the detector optimization tool to optimize the detector voltage if you notice the sensitivity of the system seems low.
SCIEX OS software enables automated tuning for the SCIEX Triple Quad 7500 system and the X500 series QTOF systems by calibrating all scans across all modes for added confidence that your system is ready to use with fast, easy and simple tuning.
Your instrument will be calibrated correctly with built-in acceptance criteria for a higher first-time success rate, saving you a significant amount of time.
A single calibrant for both positive and negative mode means:
Use one LC method for multiple MS methods to reduce method development time, explore different MS methods and simplifying method management.
The navigation tools in the Explorer workspace allow you to quickly move through the samples for an overview of your data. You can view the data in several ways depending on your preference.
Save time when you need to dig deeper into the raw data, with a click of the mouse. PeakView software is wrapped inside SCIEX OS software in the Explorer workspace. Easily launch the Explore workspace from the peak review pane in Analytics in one click!
Spend less time digging for answers. Only review data of interest with flag-based labelling and filtering tools.
SCIEX OS software has the ability to support “IF” statements for your analysis queries. There is functionality to execute calculations within the “IF” statement. “IF” statements can be built into the flagging rules when the outcome is a numeric value. Some of the data analysis you wish to conduct may be complex, therefore there is no limitation on the formula size of your query. Nested “IF” statements are also supported, and they can be packaged into a .frml file format and shared.
Import processing methods into SCIEX OS software. Your Analyst software or MultiQuant software processing methods can be imported directly into SCIEX OS software.
Driven by MS and MS/MS data analysis coupled with extensive libraries, Molecule Profiler software delivers highly accurate and flexible workflows for determining impurities and biotransformations for a wide variety of therapeutic molecules.
Molecule Profiler is fully integrated as part of SCIEX OS, and has the same look and feel. Easily multitask with other functions in SCIEX OS. And, there is no need to move data around.
The Configuration workspace displays active devices, allowing you to activate or deactivate the hardware in your workflow.
The Configuration workspace also provides the ability to add devices you may need or edit the configuration of your instruments. Within the workspace, you can adjust settings for queue management, such as maximum idle time allowed before the system goes into standby and the maximum number of samples allowed. There are also rule settings that advise users on what to do when a sample is missing, for example. If you are operating one of the X500 series QTOF instruments, you can specify calibration settings and what the system should do if there is a calibration failure.
Easily set up and manage multiple devices on one mass spectrometer. You can add devices individually and simply check the box next to the device you want to activate.
The Library workspace is used to import a library that you would like to use as part of your workflow. Libraries provide additional confirmation and assurances for confirm your data acquisitions. You can import a LibraryView software package or your own custom library.
During this process, you can select which compounds you would like to include in your processing. You may want to include every compound in the SCIEX All-in-One HR-MS/MS library, for instance, or just extract the compounds that are crucial to your experiment.
Easily add new compounds to MS/MS libraries directly from the peak review pane, making library building a breeze!
The Event Log workspace shows you useful diagnostic information and events happening within SCIEX OS software. Within this workspace, you can archive a log at your specific intervals. You can also open previously archived event logs here, so you can dig into any of the information that may be of use.
All events, all in one place. You can see and export all events, or you can select devices or workspaces to see specific events.
From compliant routine analyses to flexible research workflows, the intuitive Audit Trail workspace ensures full traceability and accountability. It includes built-in data integrity features that allow you to tailor each functionality specifically to your lab's compliance and data security requirements.
SCIEX integrated compliance services include integrated analytical instrument qualification and software validation packages that cover your complete SCIEX system workflow.
Learn more about SCIEX compliance servicesAll events, all in one place. You can see and export all events, or you can select devices or workspaces to see specific events.
Increase your productivity. Consistently deliver high-quality, actionable data from your mass spectrometry workflows with easy-to-learn SCIEX OS software.
Create an integrated experience across any and all of your SCIEX instruments (including SCIEX Triple Quad, QTRAP and QTOF systems).
The accuracy, precision and stability of SCIEX OS software helps ensure your data quality—batch after batch and throughout every stage of your MS workflow—remains uncompromised.
SCIEX OS software is the platform for an exciting, data-rich workflow called scout triggered MRM (stMRM). Intelligent monitoring of the designated marker analytes increases efficiency and reduces the demand for method maintenance. An stMRM license unlocks your SCIEX Triple Quad system to obtain better-quality data across vast screening workflows.
With standard Scheduled MRM (sMRM), you define retention time windows for each transition in your method. Instead of RT windows, Scout triggered MRM uses exogenously spiked compounds, such as an internal standard or marker compound to trigger the acquisition of groups of dependent MRMs.
Easy method maintainance
Employ stMRM to stagger marker compounds across the run and trigger groups of dependent MRMs without using RT.
Simple method transfer
With no dependence on RT, stMRM workflows are not affected by changing LC conditions like a standard sMRM method.
Laboratories with multiple instruments can now use the SCIEX OS software Central Administrator Console (CAC) to create and manage projects.
SCIEX OS software is now available in Simplified Chinese, Japanese, Korean, German, Italian, French, Spanish, Portuguese and English.
Translate the user interface by selecting your preferred language in the Configuration workspace. This allows you to more easily communicate with internal laboratories, while providing flexibility for global collaboration and to seize new opportunities. Continuity and compliance can be maintained with an option for the audit trail to remain in English.
The Echo® MS system powered by SCIEX OS software. Automated processing and enhanced data visualization tools enable scalability of ultra-high throughput workflows such as drug pipeline development, while maintaining the quality and integrity of the results.
SCIEX OS software powers up all targeted, non-targeted and suspect screening workflows analyzed with your SCIEX QTRAP, ZenoTOF, TripleTOF and X500 QTOF series instruments. Automated custom flagging and filtering tools enable rapid data review and real-time decision making. All with high levels of confidence.
SCIEX OS software is the complete software platform for the SCIEX Triple Quad 7500, 6500+ series, 5500+ series and 4500 systems. With its automated tools simplifying peak finding and integration, and calibration curve review, SCIEX OS software helps you reach new levels of precision across all your quantitative workflows.
Acquisition, control and quantification and qualification processing.
Quantification and qualification processing.
Optimized quantification processing.
ZenoTOF 7600 system
Triple Quad systems:
X500 series QTOF systems
TripleTOF systems:
QTRAP systems:
Triple Quad systems:
TripleTOF systems:
QTRAP systems:
SCIEX innovation is driven by customer needs and collaboration. Because of this, SCIEX will always improve and evolve its mass spectrometry software. Since the launch of SCIEX OS software in 2015, there have been several advancements in testing capabilities, functionality and productivity.
Software upgrades (version 3.0 to 3.1) for eligible software
Software updates (includes point releases and hotfixes)
Access to premium Learning Hub and knowledge base content online
Priority access to remote software support (during business hours) via telephone and SCIEX Now
Discounted rates on selected software licenses and related software services
Discounted rates for validation and compliance services for easier upgrades
Incorporate electronic audit trails, electronic signatures and detailed security configurations to support GxP and 21 CFR Part 11 regulations. SCIEX OS software offers the flexibility to tailor and deploy security policies that help you meet the requirements of your laboratory.
Sarah-Jane Pierre
Senior Scientist - Toxicology // Australian Clinical Labs
Lieve Dillen, Senior Principal Scientist
Assay Development and Analytical Support Development Bioanalysis Group Janssen R&D, Belgium
Sam Mallard, Senior Analytical Instrument Chemist
Australian Superintendence Company
Alex Krotulski, Program Manager
NPS Discovery // CFSRE // Philadelphia // Pennsylvania // US
Rachel Rowlinson
Specialist in Protein Mass Spectrometry // Peak Proteins, UK