Technology innovation such as high-resolution accurate mass spectrometry has paved the way toward a comprehensive study of the exposome.
The exposome was introduced by C.P. Wild in 2005 as a concept for studying the relationship between chemical exposures and nonchemical factors (such as diet, lifestyle and social behaviors) and how these interact with the unique characteristics of humans (such as genetics, physiology and epigenetics) to impact our health. 1-3
This multi-disciplinary approach has been adopted by many research areas, including environmental epidemiology, health risk assessment and environmental and human biomonitoring.4-6 Traditional measurements of exposure include targeted monitoring and untargeted discovery of unknown chemicals.1,4 Exposomics takes this a step further to measure internal exposures, relying on metabolomics, lipidomics and proteomics to assess health and disease effects.
The exposome deals with thousands of environmental factors that vary by time, place and source. The most significant challenge for epidemiological research is that these factors fluctuate over a lifetime, changing due to aging, infections, lifestyle, stress, preexisting disease, psychosocial issues and other factors.7 Moreover, as with most omics-based studies, exposomics also needs you to analyze a wide range of molecules with varying chemical properties and a broad range of concentrations.
Clearly you need a characterization strategy that is effective for targeted and non-targeted screening and quantification.
High-throughput analysis using high-resolution accurate mass spectrometry
Expand the potential of your exposomics analysis with high-resolution accurate mass spectrometry. SCIEX high-resolution accurate mass spectrometry offers you specificity, sensitivity and reliability for your qualitative and quantitative environmental analyses, including targeted and non-targeted screening methods. Get ready to:
Detect and identify low levels of chemicals in complex matrices
Reduce the risk of missing a critical component, while skipping out on laborious sample preparation, with SWATH® Acquisition
Perform targeted library database searching to quickly identify known chemical hazards
Survey for unknowns with smart and effective software that delivers easy-to-use structural elucidation tools for reliable compound identification
Miller, G.W. and Jones, D.P. The nature of nurture: refining the definition of the exposome. Toxicological Sciences 2013, 137(1), 1–2. doi: 10.1093/toxsci/kft251
Wild, C.P. Complementing the genome with an "exposome": the outstanding challenge of environmental exposure measurement in molecular epidemiology. Cancer Epidemiology Biomarkers & Prevention 2005, 14(8), 1847–1850. doi: 10.1158/1055-9965.epi-05-0456
Rappaport, S.M. Implications of the exposome for exposure science. Journal of Exposure Science & Environmental Epidemiology 2010, 21(1), 5–9. doi: 10.1038/jes.2010.50
Lioy, P.J. and Rappaport, S.M. Exposure science and the exposome: an opportunity for coherence in the environmental health sciences. Environmental Health Perspectives 2011, 119(11), a466–a467. doi: 10.1289/ehp.1104387
Dennis, K.K.; Marder, E.; Balshaw, D.M. et al. Biomonitoring in the era of the exposome. Environmental Health Perspectives 2017, 125(4), 502–510. doi: 10.1289/ehp47
Rappaport, S.M. and Smith, M.T. Environment and disease risks. Science 2010, 330(6003), 460–461. doi: 10.1126/science.1192603
6-month study of the pesticide desphenyl-chloridazon in natural water
X500R QTOF System
This easy-to-use accurate mass spectrometer system analyzes data faster using the power of SWATH® Acquisition.